A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer

Korábbi kezelés

• Previous bilateral salpingectomy or bilateral salpingo-oophorectomy
• Presence of ESSURE, or other tubal-implanted birth control at the time of surgery

Más betegség

• Known inherited ovarian cancer susceptibility
  • Part II
• Personal history of a gynecologic malignancy
• Carrier of a hereditary breast or ovarian cancer variant (e.g., BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2)
• Emergent procedure or emergency procedure that has to be completed within 24 hours where clinical consent occurs in the inpatient setting or where the patient's immediate well-being is in danger or condition may be life threatening
• Known history of pelvic fibrosis or significant adhesions.

Egyéb

• Part I
• Not fluent in English or Spanish
  • ° If there is a non-english or non-spanish speaking participant who is a strong candidate and meets all other criteria for Part 2, they are able to go directly onto Part 2 without completing Part 1. (Please see additional details in section 4.1 and 7.0.)
• Suspicious ovarian, fallopian tube, or uterine lesion on preoperative imaging
• Current pregnancy
• Primary surgeon anticipates that OS will add significant time (>30-40min) to the planned procedure.
• Inability to access the pelvis (ex., patient prone/lateral position) during the planned procedure.
• Procedures with palliative intent only

• Part I
• Age ≥45 years
• Scheduled visit with a nongynecologic surgeon
• Female or assigned female at birth
  • Part II
• Age ≥45 years
• At least one in situ fallopian tube
• No desire or plan to have children in the future
• Average risk of developing ovarian cancer
  • ° Note: Average risk patients are defined as patients with no known genetic risk factor for developing ovarian cancer. Patients who, after obtaining family history, are suspected to have a hereditary ovarian cancer syndrome but have not yet been tested, will be referred for genetic evaluation.
• Planned nongynecologic, intraabdominal, or pelvic surgery
• Deemed to be a suitable candidate by gynecologic surgeon and primary nongynecologic surgeon (for example, on the basis of surgical history and current malignancy status)
• Approved and signed informed consent