Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults

Korábbi kezelés

• Antibiotics intake during 3 months prior to the study due to possible interference with metabolic parameters
• Known alcohol, substance or drug abuse, concomitant medication
• Therapy with antidepressants within the past 6 months
• Regular therapy with acetylsalicyclic acid or current medication to regulate blood sugar, blood pressure or lipids

Más betegség

• Food intolerances, allergies and sensitivities (severe food allergies) or dietary restrictions (e.g. vegan lifestyle)
• Diabetes

Laborértékek

• Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.

Egyéb

• Participants who have a fasting period of > 12h per day on a regular basis and do not eat at least three main meals per day.
• Current habitual use of dietary supplements (e.g., vitamins, minerals) and/or unwillingness to cease intake of dietary supplements.
• More than four hours of physical exercise per week
• Women who are pregnant, breast-feeding or aiming to become pregnant during course of the trial
• Women and men on hormonal supplementation
• Women with an irregular menstrual cycle according to the FIGO criteria
• Participants likely to fail to comply with the study protocol
• Participants who do not give informed consent

• Age between 18-50 years, both inclusive
• Obese, BMI between 30 and 40 kg/m\^2 (obesity grade I or II), both inclusive
• Non-smoker
• Good knowledge of German or English language
• Stable weight change (change < +/- 3% current bodyweight) for 3 months prior to the study
• HbA1c < 6.5% without glucose lowering medication
• LDL-cholesterol < 4.6mmol/l without lipid lowering medication