Neo-Sequence 2：NCT Plus Anti-angiogenesis Therapy and Immunotherapy for LADGC

Korábbi kezelés

• Diagnose immunodeficiency or active autoimmune diseases, have received or are currently receiving immunomodulators, systemic steroid therapy, or immunosuppressive drugs within the past two years;
• Previously suffered from other tumors, excluding cured skin cancer and cervical cancer in situ;

Más betegség

• Gastrointestinal obstruction or recurrent bleeding cannot be controlled;
• Uncontrollable hypertension, severe kidney disease, and significant cardiovascular and cerebrovascular diseases;
• Active infections that require systemic treatment;
• Internal medicine diseases that do not meet the chemotherapy criteria at the same time;
• Individuals with a history of mental illness and poor compliance.

Egyéb

• Those who cannot swallow pills;
• Interstitial pneumonia;
• Moderate to severe cirrhosis caused by any reason;
• Pregnant and lactating patients;

• Local advanced diffuse or mixed type gastric cancer detected by pathology and endoscopy;
• Chest, abdomen, and pelvis enhanced CT, neck and supraclavicular ultrasound, gastroscopy, and endoscopic ultrasound were used to diagnose T3-4NanyM0 gastric cancer or gastroesophageal junction cancer (refer to AJCC staging, 8th edition);
• Has not received any anti-tumor treatment for gastric cancer yet;
• Age range from 18 to 75 years old;
• ECOG score 0-1 points;
• Liver and kidney function and blood routine meet the following conditions:
  • Neutrophils>1.5G/L, Hb>90g/L, PLT>100G/L; ALT and AST<2.5ULN; TBIL<1.5 ULN; Cr<1.0ULN;
• Left ventricular ejection fraction>60%;
• Good compliance and ability to accept long-term follow-up;
• Sign informed consent.