Evaluation of the Efficacy and Safety of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease

Korábbi kezelés

• Have undergone surgery intervention due to PD;
• Immunodeficiency or treatment with immune-modulating medication;
• Have undergone any abdominal surgery, with the exception of appendectomy, cholecystectomy, caesarean section and hysterectomy;
• Use of probiotics or antibiotics within 1 month prior to study entry;
• Presence of severe diseases related to heart, brain, kidney and lung or concomitant malignancies;

Más betegség

• Parkinsonism-plus syndrome;
• Stroke, brain trauma or epilepsy;
• Psychiatric disorder or unable to cooperate with treatment and follow-up visit;
• Presence of uncontrolled diabetes, hypertension, thyroid disease or other systemic disease;

Egyéb

• Pregnant, planning pregnancy or lactating;

• Participants who fulfill Chinese diagnostic criteria for PD (2016 edition), aged 40-75 years;
• PD Hoehn-Yahr stage 1-3
• Participants who have at least 2 of the following symptoms in the past 3 months and the symptoms have been present for at least 6 months: ① More than 25% of defecations are laborious; ② More than 25% of defecations consist of hard or lumpy stools; ③ More than 25% of defecations are accompanied by a sensation of incomplete evacuation; ④ More than 25% of defecations are accompanied by a sensation of anorectal obstruction; ⑤ More than 25% of defecations require manual assistance; ⑥ Less than 3 spontaneous bowel movements per week.
• Have taken a stable dose of anti-Parkinson drugs, antidepressants and antipsychotics for at least 1 month;
• Absence of red flags such as weight loss, hematochezia and exclusion of other diagnosis;
• Have signed the informed consent and agree to participate in this study;