NCT06417112Befejeződött
Left Atrial Strain Values as an Early Predictor of Atrial Fibrillation
Can Left Atrial Strain Measurements, and Correlating Changes in Left Atrium Area and Volume Size, be Used as an Early Predictor of Atrial Fibrillation?
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2024. máj. 16.
Rövid összefoglaló (regiszter, angolul)
Atrial fibrillation (AF) is the most common type of abnormal heart rhythm. This occurs as the chambers of the heart pump irregularly, often resulting in a fast heart rate and symptoms of irregular pounding and fluttering. There are many risk factors predisposing to AF, however, the cause cannot always be easily determined. Additionally, not all AF patients experience symptoms and consequently, this abnormal rhythm may go undetected and may be discovered accidentally. This is detrimental to patients, as untreated AF patients are at an increased risk of stroke. Patients that are suspected of having AF are referred for an ultrasound scan of the heart (echocardiogram). It is expected to see structural changes to the heart's chambers. However, structural and electrical changes of the heart may be the cause of AF but may also be a result of AF, resulting in a chicken and egg situation. It may be possible that a different type of measurement can be used during an echocardiogram to detect subtle changes in heart muscle patterns. This measurement may then serve to be an early predictor of AF. This would be determined by comparing the patterns in patients with a normal, regular rhythm to those with AF. Potential candidates are initially screened based on their echocardiogram referral. If deemed suitable for this study, the study process is explained to the patient and written informed consent is invited and received. The echocardiogram will be performed as normal with a focus on the area and volume measurements taken of one of the top chambers of the heart. An additional measurement will be taken to observe any subtle changes in the arrangement of heart cells within this same heart chamber. These measurements can be compared to each other to establish any relationship as well as compared to patients with and without AF.
- Állapot (regiszter)
- Befejeződött
- Vizsgálattípus
- Megfigyeléses
- Résztvevők száma
- 72 (tényleges)
- Első benyújtás
- 2024. máj. 12.
- Kezdés
- 2023. aug. 2.
- Elsődleges befejezés
- 2024. febr. 7.
- Fő szponzor
- Hywel Dda Health Board
- Betegségek
- Pitvarfibrilláció, Magas vérnyomás
- NCT-szám
- NCT06417112
Mit vállalsz
- Vizsgálat típusa: Megfigyeléses
- Bevont résztvevők: 72
- 2023. aug. 2. és az elsődleges befejezés (2024. febr. 7.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
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Korábbi kezelés
- Criterion 8: previous cardiac surgery.
Más betegség
- Criterion 1: subjects with any valvular pathologies in the control and disease- control groups.
Életkor
- Criterion 4: subjects < 50 years old.
Egyéb
- Criterion 2: subjects with AF that have ≥ moderate valvular pathologies (as per the British Society of Echocardiography Guidelines).
- Criterion 3: subjects with an EF < 50%.
- Criterion 5: poor quality TTE images.
- Criterion 6: inability to provide informed consent.
- Criterion 7: permanent atrial / ventricular pacing.
- Criterion 9: unsatisfactory tracking of the LA endocardial border.
- Criterion 10: patients unwilling to have their results potentially published.
Kiket keres a vizsgálat
- Criterion 1: subjects will be included in the study if they are within one of the following groups:
- Known to be in normal sinus rhythm, are normotensive and have no underlying health problems.
- Known to be in normal sinus rhythm and have controlled hypertension. This must have been diagnosed by a healthcare professional and the patient should be taking appropriate antihypertensive medication.
- Known to have chronic atrial fibrillation (persistent or permanent AF). This must have been diagnosed by a healthcare professional and the patient should be appropriately anticoagulated.
- Criterion 2: subjects should ideally be ≥ 50 years, but subjects will be age matched across all three groups.
- Criterion 3: patients should have an EF ≥ 50%.
- Criterion 4: good quality TTE images.
- Criterion 5: No valvular pathologies. o Patients with AF that have < moderate valvular pathologies may be considered (as per the British Society of Echocardiography Guidelines).
Életkor a regiszterben: 50 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Lucy Hwozdyk | Haverfordwest | Egyesült Királyság | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.