Colchicine's Efficacy in MI Patients: Comparing PCI and Non-Reperfusion Approaches

Korábbi kezelés

• Presence of concurrent diseases such as infections, inflammation, or malignancy.

Más betegség

• Diagnosed with gastrointestinal disorders including Crohn's disease, ulcerative colitis, or exhibiting chronic diarrhea.

Laborértékek

• Recent abnormal laboratory results (within the last 30 days) including:
• Hemoglobin below 11.5 g/L Leukocytes below 3.0 x 10\^9/L Platelets below 110 x 10\^9/L ALT more than three times the upper limit of normal Total bilirubin more than twice the upper limit of normal Creatinine more than twice the upper limit of normal History of liver cirrhosis, acute hepatitis exacerbation, or severe liver disease.
• History of alcohol abuse. Receiving long-term steroid therapy or using colchicine for other indications. History of hypersensitivity to colchicine. Severe renal failure (eGFR below 30). History of cardiac arrest, ventricular fibrillation, cardiogenic shock, or hemodynamic instability.

Egyéb

• Currently pregnant, breastfeeding, or planning to become pregnant during the study.
• Unwilling or unable to provide informed consent.

• Men and women aged 18 years or older. Able and willing to provide informed consent. Presenting with clinical symptoms and supporting examinations indicative of a first-time diagnosis of IMA-EST.
• Eligible for treatment according to the IMA-STEMI guidelines, which may include:
• Antiplatelet therapy Renin-angiotensin-aldosterone system inhibitors Beta-blockers
• Specifically, includes patients who have:
• Undergone early PCI. Not received reperfusion therapy. Female patients must commit to avoiding pregnancy during the study. Willing to participate in follow-up via face-to-face or telephone contact.