Clinical Study of Cord Blood-Derived CAR-NK Cells in Gastric Cancer and Pancreatic Cancer

Korábbi kezelés

• Patients who have received CAR-T,CAR-NK,TCR-T and other cell therapy targeting Claudin18.2 within 3 months before study treatment;

Más betegség

• History of other tumors;
• Patients with hypersensitivity to cell therapy or any related drugs;
• Active autoimmune diseases;
• Active infections that cannot be controlled;
• HIV infection, uncontrolled HBV, HCV and syphilis infections;
• Have metastatic disease of the central nervous system (CNS), leptomeningeal disease or spinal cord compression;
• Patients with severe heart disease;
• Patients with unstable/active ulcers or bleeding from the digestive system;
• Patients with a history of bleeding or bleeding tendency in the digestive system;

Egyéb

• Pregnant or lactating women;
• There are other factors that the researcher believes are not suitable for participating in the trial.

• Male or female aged 18-75 years (inclusive);
• Understands and voluntarily signs a written informed consent form, and is willing and able to comply with all trial requirements;
• Patients with advanced gastric cancer and advanced pancreatic cancer confirmed by histopathology or cytology, who have failed standard treatment or cannot tolerate standard treatment, including but not limited to: pancreatic cancer and gastric cancer;
• Immunohistochemical (IHC) detection of CLDN18.2, the positive expression of CLDN18.2 in tumors must be ≥ 10%;
• At least 1 measurable lesion according to RECIST 1.1;
• ECOG score is 0-1;
• All toxic reactions caused by previous antineoplastic therapy were resolved to grade 0-1 (according to NCI CTCAE 5.0 edition); Expected survival ≥ 12 weeks;
  • In addition to the primary disease, no serious hematology, heart and lung, liver and kidney disease, laboratory tests meet the following requirements:
  • Peripheral blood neutrophil absolute value ≥ 2000/mm3, platelet ≥ 50000/mm3 Serum creatinine ≤ 1.5mg/dL;ALT (alanine aminotransferase)/AST (aspartate aminotransferase) below 2.5 times the upper limit of normal; Total bilirubin ≤ 1.5mg/dL; Cardiac ejection fraction (EF)≥ 50%; International standard ratio (INR) or prothrombin time (PT) below 1.5 times the upper limit of normal; Activated partial coagulation time (aPTT) below 1.5 times the upper limit of normal; 10. Women of childbearing potential must have a negative serum pregnancy test and agree to effective birth control during the treatment phase and within 12 months after injection of CAR-NK cells; Male patients must agree to use effective birth control during the study and for 12 months after injection of CAR-NK cells.