Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)

Korábbi kezelés

• Have major medical or surgical event requiring hospitalization within the preceding 3 months
• Have taken antibiotics for 3 months before the study period
• Having active Tuberculosis (TB) or currently receiving treatment for TB
• Have any known Chronic Infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
• Enrolled in a concurrent research study judged not to be scientifically or medically compatible with this study

Más betegség

• Have major chronic disease such as heart disease or cancer
• Have any known food allergy (eg. anaphylaxis to peanuts) or skin allergy (eg. rashes due to alcohol, etc)
• Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
• History of claustrophobia

Laborértékek

• Have known glucose-6-phosphate dehydrogenase (G6PD) deficiency
• Take insulin or drugs known to affect glucose metabolism

Egyéb

• Are pregnant or contemplating pregnancy (for female subjects)
• Partake in sports at the competitive and/ or endurance levels
• Intentionally restrict food intake
• Are a smoker
• Are an overnight shift worker
• Are a member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted
• Have poor veins impeding venous access

• Male or Female
• Chinese ethnicity
• Age between 21 to 60 years• Able to give informed consent
• Body mass index (BMI) between 23 to 32 kg/m2
• Thyroid function test must be within the normal ranges
• Willing to avail yourself for the whole study and follow study procedures
• EITHER deemed to have pre-metabolic syndrome when waist circumference is > 90 cm in men or > 80 cm in women, with none or up to one of the following condition:
  • Triglyceride level >/= 1.7 mmol/L
  • HDL cholesterol </= 1.0 mmol/L in men, and </= 1.3 mmol/L in women
  • Blood pressure >/= 130/85 mmHg
  • Fasting blood glucose >/= 6.1 mmol/L
• OR deemed to have metabolic syndrome when three or more of the following conditions are present:
  • Waist circumference > 90 cm in men and > 80 cm in women
  • Triglyceride level >/= 1.7 mmol/L
  • HDL cholesterol</= 1.0 mmol/L in men, and </= 1.3 mmol/L in women
  • Blood pressure >/= 130/85 mmHg
  • Fasting blood glucose >/= 6.1 mmol/L