2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma

Korábbi kezelés

• Previous chemotherapy (except induction chemotherapy prior to surgery).
• Previous radiation therapy.

Más betegség

• Previous history of malignant tumor.
• With other serious medical conditions that may pose a greater risk or affect compliance with the test. Examples include:
• unstable heart disease that requires treatment
• kidney disease
• chronic hepatitis
• mental illness.

Laborértékek

• poorly controlled diabetes (fasting blood glucose > 1.5×ULN)

Életkor

• Age >70 years or <18 years.

Egyéb

• Treatment is palliative.
• Women who are pregnant or breastfeeding

• The pathological type is head and neck squamous cell carcinoma
• Stages III and IV
• Radical surgery has been performed with high risk factors (one of below)
• extracapsular invasion of cervical metastatic lymph nodes
• positive incisional margin or inadequate incisional margin safety distance
• No evidence of distant metastasis (M0).
• Functional status: Karnofsky scale (KPS) > 70.
• Normal bone marrow function:
• white blood cell count > 4×109/L
• hemoglobin > 120g/L in males, 110g/L in females
• platelet count > 100×109/L
• Normal liver function:
• alanine aminotransferase (ALT), aspartate aminotransferase (AST) < 1.5 times the upper limit of normal (ULN)
• alkaline phosphatase (ALP) < 2.5×ULN
• bilirubin < ULN.
• Normal renal function: creatinine clearance > 60 ml/min.
• Patients must be informed of the basic contents of this study and sign informed consent.