Exercise, Brain Activity, and Weight Maintenance

Más betegség

• Type 1 diabetes mellitus
• Active Heart or lung disease
• Severe hypertension (systolic >160 mmHg or diastolic >90 mmHg)
• MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
• Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
• History of cardiovascular disease, stroke, congestive heart failure
• Active hematological, renal, pulmonary or hepatic disorders
• Active treatment for cancer
• A history of active alcohol or substance abuse
• Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
• History of claustrophobia and inability to tolerate an MRI

Egyéb

• Peripheral neuropathy with insensate feet
• Recent blood donation within the last 2 months
• Use of beta-blockers
• Current pregnancy or breastfeeding
• Inability to exercise for any reason
• Any known contraindication to exercise testing based on current ACSM guidelines
• Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
• Body weight >250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
• Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
• Left-handedness

• Age 18-70 years
• Body mass index (BMI) >19 kg/m2 and body weight< 250kg
• Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
• In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
• Willing to adhere to the protocol requirements for the duration of the study