Local Ischemic Postconditioning in Acute Ischemic Stroke

Más betegség

• Pre ischemic stroke within past 3 months
• The expected survival time is less than 6 months, could not be followed at 90 days (such as patient with malignant tumor)
• Currently pregnant, mental disease, advanced hepatic and renal insufficiency, severe heart failure

Egyéb

• Stenosis of the proximal middle cerebral artery, internal carotid artery, or common carotid artery (≥50%) of the culprit artery
• Evidence of internal carotid artery lesion that precludes the access and application of balloon guide catheter
• Multiple vascular embolism on different pathways (e.g., bilateral MCA occlusions, or an MCA and a basilar artery occlusion)
• Participation in other interventional randomized clinical trials that may confound the outcome assessment of the trial
• Other circumstances that the investigator considers inappropriate for this trial

• Age ≥ 18 years old
• Presenting with symptoms and signs consistent with acute anterior circulation ischemic stroke
• Pre-stroke modified Rankin Score 0-1
• Baseline National Institute of Health Stroke Scale (NIHSS) score≥6
• Endovascular treatment can be initiated (femoral puncture) within 24 hours from stroke onset (stroke onset time is defined as last known well time)
• Occlusion of the intracranial internal carotid artery, or the middle cerebral artery (MCA) (M1 or M2) and is the culprit artery
• Ischemic core volume is < 70 ml, mismatch ratio is >1.8 and mismatch volume is >15 ml as determined by CT perfusion imaging
• Embolism verified as the etiology of occluded artery and modified Thrombolysis in Cerebral Infarction Score (mTICI) 2b or 3 achieved after mechanical thrombectomy.
• Time from CT perfusion to reperfusion < 2 hours
• Informed consent signed