NCT06532279Toboroz2. fázis
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
A Randomized, Masked, Placebo Controlled, Phase II Trial Of Concurrent Chemoradiation With BMX-001 In Patients With Head And Neck Squamous Cell Carcinoma Receiving Concurrent Chemoradiation
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. aug. 17.
Rövid összefoglaló (regiszter, angolul)
This phase II trial compares the effectiveness of adding BMX-001 to usual symptom management versus usual symptom management alone for reducing oral mucositis in patients who are receiving chemoradiation for head and neck cancer. Oral mucositis (inflammation and mouth sores) is a common side effect of chemoradiation that can cause pain and difficulty swallowing. Usual management of these side effects typically consists of using mouth rinses and pain medications during treatment and for several weeks after completion of treatment. BMX-001 neutralizes harmful substances in the body, preventing damage to macromolecules such as DNA and minimizes free radical-related toxicity in normal tissues. Adding BMX-001 to usual symptom management may be more effective than usual symptom management alone at reducing oral mucositis in patients receiving chemoradiation for head and neck cancer.
- Állapot (regiszter)
- Toboroz
- Fázis (regiszter)
- 2. fázis
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 98 (tervezett)
- Első benyújtás
- 2024. júl. 29.
- Kezdés
- 2025. jún. 23.
- Elsődleges befejezés
- 2027. jan. 1.
- Fő szponzor
- NRG Oncology
- Betegségek
- Fej-nyaki daganatok
- NCT-szám
- NCT06532279
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó · 2. fázis
- Tervezett résztvevők: 98
- 2025. jún. 23. és az elsődleges befejezés (2027. jan. 1.) között
- 153 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
A(z) ClinicalTrials.gov regisztermezőiből összeállítva. A vizsgálat felépítését írja le.
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Kiket keres a vizsgálat
- Patients must be planned to receive radiation and concurrent cisplatin chemotherapy as definitive therapy. Patients planned to receive concurrent cisplatin and radiation therapy in the adjuvant setting are not eligible.
- At least two subsites (buccal mucosa, lips, retromolar trigone, floor of mouth, oral tongue, tonsil, soft palate, or hard palate) must have at least 1cc or 1% of the subsite volume receiving >= 50 Gy. In cases of uncertainty, the enrolling clinician can ensure coverage by inspecting the 50 Gy isodose line and using the table describing the anatomic boundaries of the individual subsites contained within the extended cavity contour. The two or more subsites receiving >= 50 Gy must be documented by the enrolling physician.
- Pathologically confirmed (histologically or cytologically) squamous cell carcinoma of the oropharynx, larynx, hypopharynx, nasopharynx, or oral cavity.
- P16 and/or human papillomavirus (HPV) status (via polymerase chain reaction [PCR] or in situ hybridization [ISH]) must be documented for patients with oropharynx cancer.
- No patients with T0/Tx/unknown primary disease.
- No definitive clinical or radiologic evidence of metastatic (M1) disease related to current diagnosis.
- Able to receive intensity-modulated radiation therapy (IMRT) delivered as daily fractions of 2.0 Gy once per weekday with a cumulative radiation dose of 70 Gy.
- Age >= 18.
- Zubrod performance status of 0-2.
- Potassium ≥ institutional lower limit of normal (LLN) and magnesium ≥ institutional LLN. Oral or intravenous (IV) replacement therapy of potassium or magnesium is permitted if parameters can be met after repletion.
- Absolute neutrophil count (ANC) >= 1,500 cells/mm\^3.
- Platelets >= 100,000 cells/mm\^3.
- Hemoglobin >= 9.0 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 10.0 g/dl is acceptable).
- Adequate renal function defined as creatinine clearance (CrCL) > 50 mL/min by the Cockcroft-Gault formula.
- Total bilirubin =< 2 x institutional upper limit of normal (ULN) (not applicable to patients with known Gilbert's syndrome).
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x institutional ULN.
- No prior radiotherapy that would result in overlap of radiation treatment fields with planned treatment for study cancer, e.g., breast cancer with irradiation of the supraclavicular fossa/level 4 neck.
- No concurrent treatment with nitrates or other drugs that may, in the judgment of the treating investigator, create a risk for a precipitous decrease in blood pressure.
- No prior history of gross total excision of both primary and nodal disease; this includes tonsillectomy, local excision of primary site, and nodal excision that removes all clinically and radiographically evident disease. In other words, to participate in this protocol, the patient must have clinically or radiographically evident gross disease for which disease response can be assessed.
- No current treatment of adjuvant post-operative (op) chemoradiation.
- No systemic treatment with inducers or strong inhibitors of cytochrome P450 =< 4 days before registration. Note: Patients undergoing steroid treatment as a component of the anti-emetic regimen for cisplatin are eligible for the study. Treatment with the antifungal medications, nystatin, fluconazole , miconazole and clotrimazole are allowed.
- No prior induction chemotherapy treatment.
- No prior unrelated malignancy requiring current active treatment with the exception of cervical carcinoma in situ, basal cell skin carcinoma, resected T1-2N0M0 differentiated thyroid cancers, Ta bladder cancers, or low risk prostate cancer.
- No clinically significant hearing impairment that precludes cisplatin, as per physician assessment.
- No serious cardiovascular disease or cerebrovascular disease in the last 6 months prior to study enrollment; defined as a cerebrovascular accident, myocardial infarction, unstable angina, serious cardiac arrhythmia uncontrolled by medication or with the potential to interfere with protocol treatment, or current New York Heart Association (NYHA) grade II or greater congestive heart failure (CHF), or admission within last 6 months for CHF exacerbation; (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification).
- No valvular heart disease.
- No significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis) within 6 months prior to enrollment.
- No history or evidence upon physical/neurological examination of central nervous system disease (e.g., seizures) unrelated to cancer unless adequately controlled by medication.
- No acute bacterial, viral, or fungal infection requiring intravenous antimicrobials within 7 days of enrollment.
- No history of chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days of registration.
- No known personal or family history of long QT Syndrome; no marked baseline prolongation of QT/corrected QT (QTc) interval (i.e., ≥ 2 electrocardiograms [EKGs] in prior 3 months of a QTc interval > 450 milliseconds (ms) for males and > 470 ms for females using the specific/usual choice by clinical center for correction factor.
- Persistent grade 3-4 (CTCAE version 5.0) electrolyte abnormalities must be reversible to ≤ grade 1 with supplementation.
- No poorly controlled hypertension (systolic blood pressure [SBP] > 160 and/or diastolic blood pressure [DBP] > 95) over 2 repeated measures within 30 days prior to registration.
- No grade >= 2 oral mucositis per CTCAE version 5.0.
- No grade >= 2 hypotension per CTCAE v. 5.0.
- No medical necessity for anti-arrhythmics with significant risk of QTc prolongation such as class I and class III anti-arrhythmics. These include but are not limited to amiodarone, quinidine, dofetilide, sotalol, flecainide, and lidocaine.
- No medical necessity for medications listed as prohibited.
- For standard management of oral mucositis, clinicians may consult the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy. The only intervention against mucositis that is supported by level I evidence is low-level laser therapy (LLLT). Honey is rated at level II and benzydamine, which isn't available in the United States (US), is rated at level III. There are no other positively rated interventions.
- LLLT is prohibited in this study as its availability remains limited, it is not Food and Drug Administration (FDA) approved in the US, and it is considered investigational in many circumstances requiring enrollment in a dedicated protocol who requirements could conflict with this one. Therefore, institutions that use LLLT should only enroll patients who would not be eligible for (or do not want) that intervention. Honey is not on the list of prohibited medications for this study. Given the MASCC recommendation, benzydamine is allowed, although there is lack of availability in the United States of America (USA). The other listed prohibited medications are not recommended by MASCC and some are potentially harmful, such as glutamine, which is associated with mortality in patients receiving stem cell transplant.
- No history of allergic reaction to the study agent(s), compounds of similar chemical or biologic composition to the study agent (s) (or any of its excipients).
- Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal.
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (153)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Summa Health System - Akron Campus | Akron | Egyesült Államok | Toboroz |
| Atrium Health Stanly/LCI-Albemarle | Albemarle | Egyesült Államok | Toboroz |
| University of New Mexico Cancer Center | Albuquerque | Egyesült Államok | Toboroz |
| McFarland Clinic - Ames | Ames | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Egyesült Államok | Toboroz |
| Langlade Hospital and Cancer Center | Antigo | Egyesült Államok | Toboroz |
| Northwest Wisconsin Cancer Center | Ashland | Egyesült Államok | Toboroz |
| Greater Baltimore Medical Center | Baltimore | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Bay City | Bay City | Egyesült Államok | Toboroz |
| OSF Saint Joseph Medical Center | Bloomington | Egyesült Államok | Toboroz |
| Illinois CancerCare-Bloomington | Bloomington | Egyesült Államok | Toboroz |
| Boston Medical Center | Boston | Egyesült Államok | Toboroz |
| Keck Medicine of USC Buena Park | Buena Park | Egyesült Államok | Felfüggesztve |
| Illinois CancerCare-Canton | Canton | Egyesült Államok | Toboroz |
| Aultman Health Foundation | Canton | Egyesült Államok | Toboroz |
| Saint Francis Medical Center | Cape Girardeau | Egyesült Államok | Toboroz |
| Mercy Hospital | Cedar Rapids | Egyesült Államok | Toboroz |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Egyesült Államok | Toboroz |
| Chambersburg Hospital | Chambersburg | Egyesült Államok | Toboroz |
| Atrium Health University City/LCI-University | Charlotte | Egyesült Államok | Toboroz |
| Atrium Health Pineville/LCI-Pineville | Charlotte | Egyesült Államok | Toboroz |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | Egyesült Államok | Toboroz |
| Northwestern University | Chicago | Egyesült Államok | Toboroz |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Clarkston | Clarkston | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Egyesült Államok | Toboroz |
| Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Egyesült Államok | Toboroz |
| Ohio State University Comprehensive Cancer Center | Columbus | Egyesült Államok | Toboroz |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Egyesült Államok | Toboroz |
| Atrium Health Cabarrus/LCI-Concord | Concord | Egyesült Államok | Toboroz |
| Carle at The Riverfront | Danville | Egyesült Államok | Toboroz |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Egyesült Államok | Toboroz |
| Iowa Methodist Medical Center | Des Moines | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Egyesült Államok | Toboroz |
| Mercy Medical Center - Des Moines | Des Moines | Egyesült Államok | Toboroz |
| Wayne State University/Karmanos Cancer Institute | Detroit | Egyesült Államok | Toboroz |
| Miller-Dwan Hospital | Duluth | Egyesült Államok | Toboroz |
| Duke University Medical Center | Durham | Egyesült Államok | Toboroz |
| Shaw Cancer Center | Edwards | Egyesült Államok | Toboroz |
| Carle Physician Group-Effingham | Effingham | Egyesült Államok | Toboroz |
| Baptist Health Hardin | Elizabethtown | Egyesült Államok | Toboroz |
| UC San Diego Health System - Encinitas | Encinitas | Egyesült Államok | Toboroz |
| Ephrata Cancer Center | Ephrata | Egyesült Államok | Toboroz |
| UPMC Hillman Cancer Center Erie | Erie | Egyesült Államok | Toboroz |
| Illinois CancerCare-Eureka | Eureka | Egyesült Államok | Toboroz |
| Weisberg Cancer Treatment Center | Farmington Hills | Egyesült Államok | Toboroz |
| UPMC Cancer Center at UPMC Horizon | Farrell | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Flint | Flint | Egyesült Államok | Toboroz |
| Illinois CancerCare-Galesburg | Galesburg | Egyesült Államok | Toboroz |
| Levine Cancer Institute-Gaston | Gastonia | Egyesült Államok | Toboroz |
| CaroMont Regional Medical Center | Gastonia | Egyesült Államok | Toboroz |
| Northwestern Medicine Cancer Center Delnor | Geneva | Egyesült Államok | Toboroz |
| Adams Cancer Center | Gettysburg | Egyesült Államok | Toboroz |
| Arizona Center for Cancer Care - Gilbert | Gilbert | Egyesült Államok | Toboroz |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Egyesült Államok | Toboroz |
| Baptist Cancer Center-Grenada | Grenada | Egyesült Államok | Toboroz |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Egyesült Államok | Toboroz |
| Penn State Milton S. Hershey Medical Center | Hershey | Egyesült Államok | Toboroz |
| Hayworth Cancer Center | High Point | Egyesült Államok | Toboroz |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Egyesült Államok | Toboroz |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Egyesült Államok | Toboroz |
| University of Kansas Cancer Center | Kansas City | Egyesült Államok | Toboroz |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Egyesült Államok | Toboroz |
| University of Tennessee - Knoxville | Knoxville | Egyesült Államok | Toboroz |
| UC San Diego Moores Cancer Center | La Jolla | Egyesült Államok | Toboroz |
| Lancaster Radiation Therapy Center | Lancaster | Egyesült Államok | Toboroz |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Egyesült Államok | Toboroz |
| Sechler Family Cancer Center | Lebanon | Egyesült Államok | Toboroz |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | Egyesült Államok | Toboroz |
| Los Angeles General Medical Center | Los Angeles | Egyesült Államok | Felfüggesztve |
| USC / Norris Comprehensive Cancer Center | Los Angeles | Egyesült Államok | Felfüggesztve |
| Illinois CancerCare-Macomb | Macomb | Egyesült Államok | Toboroz |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Egyesült Államok | Toboroz |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Egyesült Államok | Toboroz |
| Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Egyesült Államok | Toboroz |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Egyesült Államok | Toboroz |
| Medical College of Wisconsin | Milwaukee | Egyesült Államok | Toboroz |
| Zablocki Veterans Administration Medical Center | Milwaukee | Egyesült Államok | Toboroz |
| Atrium Health Union/LCI-Union | Monroe | Egyesült Államok | Toboroz |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Egyesült Államok | Toboroz |
| UPMC Cancer Center - Monroeville | Monroeville | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Macomb | Mount Clemens | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Egyesült Államok | Toboroz |
| ProHealth D N Greenwald Center | Mukwonago | Egyesült Államok | Fut, nem toboroz |
| Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Egyesült Államok | Toboroz |
| Baptist Health Floyd | New Albany | Egyesült Államok | Toboroz |
| UPMC Hillman Cancer Center - New Castle | New Castle | Egyesült Államok | Toboroz |
| USC Norris Oncology/Hematology-Newport Beach | Newport Beach | Egyesült Államok | Felfüggesztve |
| Sarasota Memorial Hospital-Venice | N. Venice | Egyesült Államok | Toboroz |
| Northwestern Medicine Oak Brook | Oak Brook | Egyesült Államok | Toboroz |
| Drexel Town Square Health Center | Oak Creek | Egyesült Államok | Toboroz |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Egyesült Államok | Fut, nem toboroz |
| University of Oklahoma Health Sciences Center | Oklahoma City | Egyesült Államok | Toboroz |
| Northwestern Medicine Orland Park | Orland Park | Egyesült Államok | Toboroz |
| Lake Regional Hospital | Osage Beach | Egyesült Államok | Toboroz |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Egyesült Államok | Toboroz |
| Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Egyesült Államok | Toboroz |
| Illinois CancerCare-Pekin | Pekin | Egyesült Államok | Toboroz |
| Arizona Center for Cancer Care-Peoria | Peoria | Egyesült Államok | Toboroz |
| Illinois CancerCare-Peoria | Peoria | Egyesült Államok | Toboroz |
| OSF Saint Francis Medical Center | Peoria | Egyesült Államok | Toboroz |
| Illinois CancerCare-Peru | Peru | Egyesült Államok | Toboroz |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Egyesült Államok | Toboroz |
| Arizona Center for Cancer Care - Phoenix | Phoenix | Egyesült Államok | Toboroz |
| UPMC-Saint Margaret | Pittsburgh | Egyesült Államok | Toboroz |
| UPMC-Shadyside Hospital | Pittsburgh | Egyesült Államok | Toboroz |
| UPMC-Passavant Hospital | Pittsburgh | Egyesült Államok | Toboroz |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Egyesült Államok | Toboroz |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Egyesült Államok | Toboroz |
| McLaren-Port Huron | Port Huron | Egyesült Államok | Toboroz |
| Illinois CancerCare-Princeton | Princeton | Egyesült Államok | Toboroz |
| Renown Regional Medical Center | Reno | Egyesült Államok | Toboroz |
| Aspirus Cancer Care - James Beck Cancer Center | Rhinelander | Egyesült Államok | Toboroz |
| VCU Massey Cancer Center at Stony Point | Richmond | Egyesült Államok | Toboroz |
| VCU Massey Comprehensive Cancer Center | Richmond | Egyesült Államok | Toboroz |
| Levine Cancer Institute-Rock Hill | Rock Hill | Egyesült Államok | Toboroz |
| Rock Hill Radiation Therapy Center | Rock Hill | Egyesült Államok | Toboroz |
| Moffitt Cancer Center at SouthShore | Ruskin | Egyesült Államok | Toboroz |
| Dartmouth Cancer Center - North | Saint Johnsbury | Egyesült Államok | Toboroz |
| Salina Regional Health Center | Salina | Egyesült Államok | Toboroz |
| UC San Diego Medical Center - Hillcrest | San Diego | Egyesült Államok | Toboroz |
| Sarasota Memorial Hospital | Sarasota | Egyesült Államok | Toboroz |
| Florida Cancer Specialists - Sarasota Downtown | Sarasota | Egyesült Államok | Toboroz |
| Sarasota Memorial Health Care Center at University Parkway | Sarasota | Egyesült Államok | Toboroz |
| Florida Cancer Specialists - Sarasota | Sarasota | Egyesült Államok | Toboroz |
| Arizona Center for Cancer Care - Scottsdale | Scottsdale | Egyesült Államok | Toboroz |
| Atrium Health Cleveland/LCI-Cleveland | Shelby | Egyesült Államok | Toboroz |
| Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Egyesült Államok | Toboroz |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Egyesült Államok | Toboroz |
| Arizona Center for Cancer Care-Surprise | Surprise | Egyesült Államok | Toboroz |
| Moffitt Cancer Center - McKinley Campus | Tampa | Egyesült Államok | Toboroz |
| Moffitt Cancer Center-International Plaza | Tampa | Egyesült Államok | Toboroz |
| Moffitt Cancer Center | Tampa | Egyesült Államok | Toboroz |
| Arizona Center for Cancer Care | Tempe | Egyesült Államok | Toboroz |
| Montefiore Medical Center - Moses Campus | The Bronx | Egyesült Államok | Toboroz |
| Montefiore Medical Center-Einstein Campus | The Bronx | Egyesült Államok | Toboroz |
| Carle Cancer Center | Urbana | Egyesült Államok | Toboroz |
| Florida Cancer Specialists - Venice Pinebrook | Venice | Egyesült Államok | Toboroz |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Egyesült Államok | Toboroz |
| Illinois CancerCare - Washington | Washington | Egyesült Államok | Toboroz |
| George Washington University Medical Center | Washington D.C. | Egyesült Államok | Toboroz |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Egyesült Államok | Toboroz |
| UW Cancer Center at ProHealth Care | Waukesha | Egyesült Államok | Fut, nem toboroz |
| Aspirus Regional Cancer Center | Wausau | Egyesült Államok | Toboroz |
| Moffitt Cancer Center at Wesley Chapel | Wesley Chapel | Egyesült Államok | Toboroz |
| Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Egyesült Államok | Toboroz |
| University of Cincinnati Cancer Center-West Chester | West Chester | Egyesült Államok | Toboroz |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Egyesült Államok | Toboroz |
| Wake Forest University Health Sciences | Winston-Salem | Egyesült Államok | Toboroz |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Egyesült Államok | Toboroz |
| WellSpan Health-York Cancer Center | York | Egyesült Államok | Toboroz |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.