Extracellular Vesicles, Insulin Action, and Exercise

Korábbi kezelés

• Participants prescribed metformin, GLP-1 agonists (oral/injectable), TZDs, DPP-IV inhibitors, Acarbose, SGLT-2 inhibitors within 6 year.

Más betegség

• Evidence of type 1 diabetes and diabetics requiring insulin therapy.
• History of significant metabolic, cardiac, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures, or impact subject safety.
• Known hypersensitivity to perflutren (contained in Definity).

Laborértékek

• T2D with HbA1c ≥10.0%
• Hypertriglyceridemic (≥400 mg/dl) and hypercholesterolemic (≥260 mg/dl) participants as determined from LabCorp samples.
• Kidney dysfunction as determined from LabCorp biochemical outcomes (e.g. creatinine (≥1.0 mg/dl), eGFR (≤59 ml/min/1.73), BUN (≥24 mg/dl) as derived from comprehensive metabolic panels).
• Abnormal liver function (reflective from comprehensive panel liver enzymes Alk (≥121 IU/L), AST (≥40 IU/L) and ALT (≥32 IU/L) via LabCorp).
• Suggested infections at time of screening as confirmed by WBC (≥10.8 x10E3/uL) and/or platelets (≥450 x10E3/uL).

Életkor

• Participants who are smokers or who have quit smoking ≤2 years ago

Egyéb

• Participants with morbid obesity (BMI >45 kg/m2) and underweight patients (BMI: ≤18 kg/m2).
• Intolerance to insulin
• Participants who have not been weight stable (≥2 kg weight change in past 6 months)
• Participants who have been recently active in past 6 months via health screening questions (≥150 min of moderate/high intensity exercise)
• Hypertensive (≥160/100 mmHg) at time of screening.
• Pregnant (as evidenced by positive pregnancy test) or nursing women
• Participants with contraindications to participation in an exercise training program
• Anemic as confirmed by hematocrit (HCT) (women ≤36%, Men ≤38%) at time of screening.

• Male or female 30 - 80 years old.
• HbA1c <5.7% and fasting glucose <100mg/dl to be considered NGT
• T2D diagnosis or confirmation HbA1c ≥6.5% and fasting glucose ≥126 mg/dl
• Prescribed metformin, GLP-1 agonists (oral/injectable), TZDs, DPP-IV inhibitors, Acarbose, SGLT-2 inhibitors ≥6 year.
• Has a body mass index of 20-24.99 or 25.0-45 kg/m2.
• Not diagnosed with Type 1 diabetes.
• Not currently engaged in >150 min/wk of exercise.