Phase 2a Study of VTX3232 in Parkinson's Disease

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• Diagnosis of a Parkinsonian syndrome other than idiopathic Parkinson's Disease.
• A diagnosis of a significant central nervous system (CNS) disease other than Parkinson's disease; history of repeated head injury or traumatic brain injury; history of epilepsy or seizure disorder other than febrile seizures as a child.
• History of brain surgery.

• Participants must be ≥ 40 years up to 80 years of age, inclusive, at the time of signing the informed consent, with BMI > 18.5 and < 32.0 kg/m2 and body weight ≥ 50.0 kg for males and ≥ 45.0 kg for females.
• Diagnosis of idiopathic Parkinson's Disease between 0 and 60 months prior to screening.
• Score of 2 or less on Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part IV at screening.
• Have not received prior treatment with deep brain stimulation (DBS).
• If receiving treatment with symptomatic PD therapies, treatment must be stable. Note: The Medical Monitor should be contacted with any questions regarding concomitant therapies.
• A female participant is eligible if they are of nonchildbearing potential
• A male participant sexually active with a woman of child bearing potential is eligible if they agree to use contraception/barrier and refrain from donating sperm during the study and for at least 90 days after the last dose