Study Targeting Myocardial Perfusion and Symptom Relief in Women With SGLT2 Inhibitors (STRONG)

Korábbi kezelés

• History of acute coronary syndrome (ACS) within previous 30 days

Más betegség

• History of congestive heart failure, severe pulmonary disease, liver disease
• Stroke within the last 180 days or intracranial hemorrhage at any time.
• Severe valvular disease
• Type 1 diabetes mellitus
• Active malignancy requiring treatment at the time of visit
• History of recurrent UTI/bladder/kidney infections
• Known or suspected broncho-constrictive or bronchospastic lung disease (ARDS, emphysema)
• Greater than first degree heart block
• Implanted cardiac device
• Profound sinus bradycardia (heart rate <40 beats per minute)
• Atrial fibrillation or supraventricular arrhythmias at time of imaging
• History of reaction to iodinated contrast agents

Laborértékek

• History of non-ischemic cardiomyopathy LVEF <40% or hypertrophic cardiomyopathy.
• Severe (eGFR <30 mL/min/1.73 m2 by CKD-EPI), unstable, or rapidly progressing renal disease at the time of randomization

Életkor

• Life expectancy <3 years, due to non-cardiovascular comorbidity.

Egyéb

• Pregnancy or women who are breast-feeding
• Symptomatic hypotension or systolic BP >95 mmHg on 2 consecutive measurements
• Asthma with ongoing wheezing
• Known intolerance of nitrates (other than hypotension)

• • Female sex.
  • Age ≥18 years.
  • Willing and able to provide written informed consent.
  • Signs and symptoms of suspected ischemia prompted referral for further evaluation by cardiac catheterization or CCTA within two years of consent.
  • No evidence of obstructive epicardial CAD (stenosis <50%) of a major epicardial vessel or an FFR ≤0.80 by invasive catheterization or CCTA. Patients who have not undergone cardiac catheterization of CT angiogram within the last 2 years for chest pain can be scheduled for a screening CT angiogram of the coronary arteries to confirm eligibility.
  • Diagnosis of CMD defined by CFR \&lt; 2 by CMR
  • Never on SGLT2i