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Taking people in Egyesült Államok2/3. fázis

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

Key facts

Where
Aberdeen, Albuquerque, Amarillo, Anaconda, Anaheim, Anchorage, Anderson, Ashland, Athens, Atlanta, Augusta, Aurora, Baker City, Baldwin Park, Baltimore, Barrington, Beaver, Bel Air, Belfast, Bellflower, Bemidji, Bettendorf, Beverly, Beverly Hills, Billings, Bismarck, Bloomington, Bluffton, Boise, Bozeman, Brainerd, Brewer, Bridgeport, Brighton, Brunswick, Burlington, Butler, Caldwell, Cameron Park, Canton, Cape Girardeau, Carthage, Cedar Rapids, Centerville, Chambersburg, Charleston, Charlottesville, Chelsea, Chicago, Chico, City of Saint Peters, Cleveland, Coeur d'Alene, Collierville, Columbus, Concord, Coon Rapids, Cranberry Township, Creve Coeur, Crown Point, Crystal Lake, Cudahy, Cumberland, Damariscotta, Danville, Daphne, Dayton, Decatur, Deer River, DeKalb, Delaware, Derby, Dixon, Downers Grove, Duarte, Dublin, Duluth, Durham, Dyer, East Hills, Edina, Effingham, Elgin, Ephrata, Erie, Escanaba, Eureka, Fairfield, Fairhope, Fairway, Fargo, Farmington, Farrell, Flint, Fontana, Franklin, Fresno, Fruitland, Gaffney, Gainesville, Gaithersburg, Galesburg, Geneva, Germantown, Gettysburg, Glastonbury, Glenview, Gloucester, Grafton, Grayslake, Great Falls, Green Bay, Greensburg, Greenville, Greenwich, Greer, Grenada, Guilford, Gulfport, Hanover, Harbor City, Harrisburg, Hartford, Hays, Hazel Crest, Hibbing, Hilton Head Island, Hobart, Huntington, Indiana, Indianapolis, Iowa City, Irvine, Johns Creek, Johnstown, Jonesboro, Kalispell, Kansas City, Kenosha, Kewanee, La Crosse, La Jolla, Lake Forest, Lancaster, Lansing, Largo, Lawrence, Lawrenceville, Lawton, Leavenworth, Lebanon, Lee's Summit, Lexington, Libertyville, Livonia, Loma Linda, Los Angeles, Lutherville, Lynchburg, Macomb, Madison, Manchester, Mansfield, Marinette, Marion, Marshfield, Martinsburg, Marysville, Mather, Mattoon, Maywood, McKeesport, McLean, Mechanicsburg, Memphis, Meridian, Millville, Milwaukee, Minneapolis, Missoula, Mobile, Monroeville, Moon Township, Moorestown, Morgantown, Mount Pleasant, Munster, N. Huntingdon, Nampa, Natrona Heights, New Albany, New Castle, New Haven, New Richmond, Newark, Newberg, Normal, North Haven, O'Fallon, Oak Brook, Oak Lawn, Oakland, Oconto Falls, Oklahoma City, Olathe, Ontario, Oregon City, Orland Park, Osage Beach, Oshkosh, Ottawa, Overland Park, Oxford, Palo Alto, Palos Heights, Panorama City, Park Ridge, Parkersburg, Peabody, Pekin, Peoria, Peru, Philadelphia, Pickerington, Pinehurst, Pittsburgh, Pontiac, Portland, Post Falls, Princeton, Racine, Rancho Mirage, Rapid City, Rehoboth Beach, Richmond, Riverside, Robbinsdale, Rochester, Rockport, Roseville, Sacramento, Saint Johnsbury, Saint Louis Park, Saint Paul, Sainte Genevieve, Salem, Salina, Salt Lake City, San Diego, San Francisco, San Jose, San Leandro, San Marcos, San Mateo, San Rafael, Sandpoint, Sandstone, Sanford, Santa Barbara, Santa Clara, Saraland, Savannah, Scarborough, Seneca, Sheboygan, Shiloh, Sioux Falls, South Hill, South Portland, South San Francisco, Southhaven, Spartanburg, Springfield, St Louis, Stamford, Stevens Point, Stony Brook, Sturgeon Bay, Sullivan, Summit, Sylvania, Tampa, Tarzana, The Bronx, Topeka, Torrance, Torrington, Troy, Truckee, Trumbull, Tucson, Two Rivers, Union, Uniontown, Upland, Urbana, Vallejo, Valparaiso, Virginia, Voorhees Township, Walnut Creek, Warrenville, Washington, Washington D.C., Waterbury, Waterford, Wauwatosa, Webster, West Allis, West Haven, West Islip, Westerville, Weston, Westwood, Wheeling, White River Junction, Whittier, Williamsport, Woodbridge, Woodbury, Woodland Hills, Worcester, Worthington, York és Ypsilanti, Egyesült ÁllamokSee the 413 sites
Phase
2/3. fázis

Where in Egyesült Államok

  • UM Upper Chesapeake Hematology and Oncology - AberdeenAberdeen, Egyesült ÁllamokTaking people
  • University of New Mexico Cancer CenterAlbuquerque, Egyesült ÁllamokTaking people
  • The Don and Sybil Harrington Cancer CenterAmarillo, Egyesült ÁllamokTaking people
  • Community Hospital of AnacondaAnaconda, Egyesült ÁllamokTaking people
  • Kaiser Permanente-AnaheimAnaheim, Egyesült ÁllamokTaking people
  • Katmai Oncology GroupAnchorage, Egyesült ÁllamokNo longer taking part
  • AnMed Health Cancer CenterAnderson, Egyesült ÁllamokTaking people
  • Duluth Clinic AshlandAshland, Egyesült ÁllamokTaking people
  • OhioHealth O'Bleness HospitalAthens, Egyesült ÁllamokTaking people
  • Emory Saint Joseph's HospitalAtlanta, Egyesült ÁllamokTaking people
  • Emory University Hospital MidtownAtlanta, Egyesült ÁllamokTaking people
  • Emory University Hospital/Winship Cancer InstituteAtlanta, Egyesült ÁllamokTaking people
  • Grady Health SystemAtlanta, Egyesült ÁllamokTaking people
  • Northside HospitalAtlanta, Egyesült ÁllamokTaking people
  • Harold Alfond Center for Cancer CareAugusta, Egyesült ÁllamokTaking people
  • Advocate Outpatient Center - AuroraAurora, Egyesült ÁllamokTaking people
  • Saint Alphonsus Cancer Care Center-Baker CityBaker City, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Baldwin ParkBaldwin Park, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Woodlawn Medical CenterBaltimore, Egyesült ÁllamokTaking people
  • Saint Agnes HospitalBaltimore, Egyesült ÁllamokTaking people
  • Advocate Good Shepherd HospitalBarrington, Egyesült ÁllamokTaking people
  • UPMC-Heritage Valley Health System BeaverBeaver, Egyesült ÁllamokTaking people
  • UM Upper Chesapeake Medical CenterBel Air, Egyesült ÁllamokTaking people
  • MaineHealth Waldo HospitalBelfast, Egyesült ÁllamokTaking people
  • Kaiser Permanente-BellflowerBellflower, Egyesült ÁllamokTaking people
  • Sanford Joe Lueken Cancer CenterBemidji, Egyesült ÁllamokTaking people
  • University of Iowa Healthcare Cancer Services Quad CitiesBettendorf, Egyesült ÁllamokTaking people
  • Beverly HospitalBeverly, Egyesült ÁllamokTaking people
  • Tower Cancer Research FoundationBeverly Hills, Egyesült ÁllamokTaking people
  • Billings Clinic Cancer CenterBillings, Egyesült ÁllamokTaking people
  • Sanford Bismarck Medical CenterBismarck, Egyesült ÁllamokTaking people
  • Illinois CancerCare-BloomingtonBloomington, Egyesült ÁllamokTaking people
  • Saint Joseph's/Candler - Bluffton CampusBluffton, Egyesült ÁllamokTaking people
  • Saint Alphonsus Cancer Care Center-BoiseBoise, Egyesült ÁllamokTaking people
  • Saint Luke's Cancer Institute - BoiseBoise, Egyesült ÁllamokTaking people
  • Bozeman Health Deaconess HospitalBozeman, Egyesült ÁllamokTaking people
  • Essentia Health Saint Joseph's Medical CenterBrainerd, Egyesült ÁllamokTaking people
  • Lafayette Family Cancer Center-EMMCBrewer, Egyesült ÁllamokTaking people
  • United Hospital CenterBridgeport, Egyesült ÁllamokTaking people
  • Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, Egyesült ÁllamokTaking people
  • MaineHealth Cancer Care and IV Therapy - BrunswickBrunswick, Egyesült ÁllamokTaking people
  • Aurora Cancer Care-Southern Lakes VLCCBurlington, Egyesült ÁllamokTaking people
  • Lahey ClinicBurlington, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center at Butler Health SystemButler, Egyesült ÁllamokTaking people
  • Saint Alphonsus Cancer Care Center-CaldwellCaldwell, Egyesült ÁllamokTaking people
  • Marshall Cancer CenterCameron Park, Egyesült ÁllamokTaking people
  • Aultman Health FoundationCanton, Egyesült ÁllamokTaking people
  • Illinois CancerCare-CantonCanton, Egyesült ÁllamokTaking people
  • Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, Egyesült ÁllamokTaking people
  • Saint Francis Medical CenterCape Girardeau, Egyesült ÁllamokTaking people
  • Illinois CancerCare-CarthageCarthage, Egyesült ÁllamokTaking people
  • Physicians' Clinic of Iowa PCCedar Rapids, Egyesült ÁllamokTaking people
  • Miami Valley Hospital SouthCenterville, Egyesült ÁllamokTaking people
  • WellSpan Medical Oncology and HematologyChambersburg, Egyesült ÁllamokTaking people
  • Medical University of South CarolinaCharleston, Egyesült ÁllamokTaking people
  • University of Virginia Cancer CenterCharlottesville, Egyesült ÁllamokTaking people
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, Egyesült ÁllamokTaking people
  • Advocate Illinois Masonic Medical CenterChicago, Egyesült ÁllamokTaking people
  • Northwestern UniversityChicago, Egyesült ÁllamokTaking people
  • Enloe Medical CenterChico, Egyesült ÁllamokTaking people
  • Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, Egyesült ÁllamokTaking people
  • Louis Stokes Cleveland VA Medical CenterCleveland, Egyesült ÁllamokTaking people
  • Kootenai Health - Coeur d'AleneCoeur d'Alene, Egyesült ÁllamokTaking people
  • Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, Egyesült ÁllamokTaking people
  • Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, Egyesült ÁllamokTaking people
  • Columbus Oncology and Hematology Associates IncColumbus, Egyesült ÁllamokTaking people
  • Doctors HospitalColumbus, Egyesült ÁllamokTaking people
  • Grant Medical CenterColumbus, Egyesült ÁllamokTaking people
  • Riverside Methodist HospitalColumbus, Egyesült ÁllamokTaking people
  • New Hampshire Oncology Hematology PA-ConcordConcord, Egyesült ÁllamokTaking people
  • Mercy HospitalCoon Rapids, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center - Passavant - CranberryCranberry Township, Egyesült ÁllamokTaking people
  • Siteman Cancer Center at West County HospitalCreve Coeur, Egyesült ÁllamokTaking people
  • Northwest Cancer Center - Crown PointCrown Point, Egyesült ÁllamokTaking people
  • AMG Crystal Lake - OncologyCrystal Lake, Egyesült ÁllamokTaking people
  • Aurora Saint Luke's South ShoreCudahy, Egyesült ÁllamokTaking people
  • UPMC Western MarylandCumberland, Egyesült ÁllamokTaking people
  • MaineHealth LincolnHealth HospitalDamariscotta, Egyesült ÁllamokTaking people
  • Carle at The RiverfrontDanville, Egyesült ÁllamokTaking people
  • Gulf Health Hospitals Inc/Infirmary Cancer Care - MalbisDaphne, Egyesült ÁllamokTaking people
  • Miami Valley HospitalDayton, Egyesült ÁllamokTaking people
  • Miami Valley Hospital NorthDayton, Egyesült ÁllamokTaking people
  • Premier Blood and Cancer CenterDayton, Egyesült ÁllamokTaking people
  • Atlanta VA Medical CenterDecatur, Egyesült ÁllamokTaking people
  • Cancer Care Specialists of Illinois - DecaturDecatur, Egyesült ÁllamokTaking people
  • Decatur Memorial HospitalDecatur, Egyesült ÁllamokTaking people
  • Emory Decatur HospitalDecatur, Egyesült ÁllamokTaking people
  • Essentia Health - Deer River ClinicDeer River, Egyesült ÁllamokTaking people
  • Northwestern Medicine Cancer Center KishwaukeeDeKalb, Egyesült ÁllamokTaking people
  • Delaware Health Center-Grady Cancer CenterDelaware, Egyesült ÁllamokTaking people
  • Grady Memorial HospitalDelaware, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital-Derby Care CenterDerby, Egyesült ÁllamokTaking people
  • Illinois CancerCare-DixonDixon, Egyesült ÁllamokTaking people
  • Advocate Good Samaritan HospitalDowners Grove, Egyesült ÁllamokTaking people
  • City of Hope Comprehensive Cancer CenterDuarte, Egyesült ÁllamokTaking people
  • Columbus Oncology and Hematology AssociatesDublin, Egyesült ÁllamokTaking people
  • Dublin Methodist HospitalDublin, Egyesült ÁllamokTaking people
  • Essentia Health Cancer CenterDuluth, Egyesült ÁllamokTaking people
  • Northside Hospital - DuluthDuluth, Egyesült ÁllamokTaking people
  • Durham VA Medical CenterDurham, Egyesült ÁllamokTaking people
  • Northwest Oncology LLCDyer, Egyesült ÁllamokTaking people
  • The Cancer Institute at Saint Francis HospitalEast Hills, Egyesült ÁllamokTaking people
  • Fairview Southdale HospitalEdina, Egyesült ÁllamokTaking people
  • Carle Physician Group-EffinghamEffingham, Egyesült ÁllamokTaking people
  • Crossroads Cancer CenterEffingham, Egyesült ÁllamokTaking people
  • Advocate Sherman HospitalElgin, Egyesült ÁllamokTaking people
  • Ephrata Cancer CenterEphrata, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center ErieErie, Egyesült ÁllamokTaking people
  • OSF Saint Francis Hospital and Medical GroupEscanaba, Egyesült ÁllamokTaking people
  • Illinois CancerCare-EurekaEureka, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center-FairfieldFairfield, Egyesült ÁllamokTaking people
  • Thomas HospitalFairhope, Egyesült ÁllamokTaking people
  • University of Kansas Clinical Research CenterFairway, Egyesült ÁllamokTaking people
  • Essentia Health Cancer Center-South University ClinicFargo, Egyesült ÁllamokTaking people
  • Sanford Broadway Medical CenterFargo, Egyesült ÁllamokTaking people
  • Sanford Roger Maris Cancer CenterFargo, Egyesült ÁllamokTaking people
  • Parkland Health Center - FarmingtonFarmington, Egyesült ÁllamokTaking people
  • UPMC Cancer Center at UPMC HorizonFarrell, Egyesült ÁllamokTaking people
  • Cancer Hematology Centers - FlintFlint, Egyesült ÁllamokTaking people
  • Genesys Hurley Cancer InstituteFlint, Egyesült ÁllamokTaking people
  • Genesee Hematology Oncology PCFlint, Egyesült ÁllamokNo longer taking part
  • Kaiser Permanente-FontanaFontana, Egyesült ÁllamokTaking people
  • Atrium Medical Center-Middletown Regional HospitalFranklin, Egyesült ÁllamokTaking people
  • Kaiser Permanente Fresno Orchard PlazaFresno, Egyesült ÁllamokTaking people
  • Kaiser Permanente-FresnoFresno, Egyesült ÁllamokTaking people
  • Saint Luke's Cancer Institute - FruitlandFruitland, Egyesült ÁllamokTaking people
  • Gibbs Cancer Center-GaffneyGaffney, Egyesült ÁllamokTaking people
  • Malcom Randall Veterans Administration Medical CenterGainesville, Egyesült ÁllamokTaking people
  • Northeast Georgia Medical Center-GainesvilleGainesville, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Gaithersburg Medical CenterGaithersburg, Egyesült ÁllamokTaking people
  • Illinois CancerCare-GalesburgGalesburg, Egyesült ÁllamokTaking people
  • Northwestern Medicine Cancer Center DelnorGeneva, Egyesült ÁllamokTaking people
  • Aurora Health Care Germantown Health CenterGermantown, Egyesült ÁllamokTaking people
  • Adams Cancer CenterGettysburg, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center at GlastonburyGlastonbury, Egyesült ÁllamokNo longer taking part
  • Northwestern Medicine Glenview Outpatient CenterGlenview, Egyesült ÁllamokTaking people
  • Addison Gilbert HospitalGloucester, Egyesült ÁllamokTaking people
  • Aurora Cancer Care-GraftonGrafton, Egyesült ÁllamokTaking people
  • Northwestern Medicine Grayslake Outpatient CenterGrayslake, Egyesült ÁllamokTaking people
  • Benefis Sletten Cancer InstituteGreat Falls, Egyesült ÁllamokTaking people
  • Aurora BayCare Medical CenterGreen Bay, Egyesült ÁllamokTaking people
  • Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, Egyesült ÁllamokTaking people
  • Saint Vincent Hospital Cancer Center Green BayGreen Bay, Egyesült ÁllamokTaking people
  • UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, Egyesült ÁllamokTaking people
  • Miami Valley Cancer Care and InfusionGreenville, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center at GreenwichGreenwich, Egyesült ÁllamokTaking people
  • Gibbs Cancer Center-PelhamGreer, Egyesült ÁllamokTaking people
  • Baptist Cancer Center-GrenadaGrenada, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center - GuilfordGuilford, Egyesült ÁllamokTaking people
  • Gulfport Memorial HospitalGulfport, Egyesült ÁllamokTaking people
  • WellSpan Medical Oncology and HematologyHanover, Egyesült ÁllamokTaking people
  • Kaiser Permanente South BayHarbor City, Egyesült ÁllamokTaking people
  • UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center at Saint FrancisHartford, Egyesült ÁllamokNo longer taking part
  • HaysMedHays, Egyesült ÁllamokTaking people
  • Advocate South Suburban HospitalHazel Crest, Egyesült ÁllamokTaking people
  • Essentia Health Hibbing ClinicHibbing, Egyesült ÁllamokTaking people
  • South Carolina Cancer Specialists PCHilton Head Island, Egyesült ÁllamokTaking people
  • Saint Mary Medical CenterHobart, Egyesült ÁllamokTaking people
  • Edwards Comprehensive Cancer CenterHuntington, Egyesült ÁllamokTaking people
  • IRMC Cancer CenterIndiana, Egyesült ÁllamokTaking people
  • Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, Egyesült ÁllamokTaking people
  • Richard L. Roudebush Veterans Affairs Medical CenterIndianapolis, Egyesült ÁllamokTaking people
  • Saint Catherine HospitalIndianapolis, Egyesült ÁllamokTaking people
  • Sidney and Lois Eskenazi HospitalIndianapolis, Egyesült ÁllamokTaking people
  • University of Iowa/Holden Comprehensive Cancer CenterIowa City, Egyesült ÁllamokTaking people
  • City of Hope at Irvine LennarIrvine, Egyesült ÁllamokTaking people
  • Kaiser Permanente-IrvineIrvine, Egyesült ÁllamokTaking people
  • Emory Johns Creek HospitalJohns Creek, Egyesült ÁllamokTaking people
  • UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, Egyesült ÁllamokTaking people
  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, Egyesült ÁllamokTaking people
  • Logan Health Medical CenterKalispell, Egyesült ÁllamokTaking people
  • Kansas City Veterans Affairs Medical CenterKansas City, Egyesült ÁllamokTaking people
  • University Health Truman Medical CenterKansas City, Egyesült ÁllamokTaking people
  • University of Kansas Cancer CenterKansas City, Egyesült ÁllamokTaking people
  • University of Kansas Cancer Center - BriarcliffKansas City, Egyesült ÁllamokTaking people
  • University of Kansas Cancer Center - NorthKansas City, Egyesült ÁllamokTaking people
  • Aurora Cancer Care-Kenosha SouthKenosha, Egyesült ÁllamokTaking people
  • Illinois CancerCare-Kewanee ClinicKewanee, Egyesült ÁllamokTaking people
  • Gundersen Lutheran Medical CenterLa Crosse, Egyesült ÁllamokTaking people
  • UC San Diego Moores Cancer CenterLa Jolla, Egyesült ÁllamokTaking people
  • Northwestern Medicine Lake Forest HospitalLake Forest, Egyesült ÁllamokTaking people
  • City of Hope Antelope ValleyLancaster, Egyesült ÁllamokTaking people
  • University of Michigan Health - Sparrow LansingLansing, Egyesült ÁllamokTaking people
  • Kaiser Permanente - Largo Medical CenterLargo, Egyesült ÁllamokTaking people
  • Lawrence Memorial HospitalLawrence, Egyesült ÁllamokTaking people
  • Northside Hospital - GwinnettLawrenceville, Egyesült ÁllamokTaking people
  • Cancer Centers of Southwest Oklahoma ResearchLawton, Egyesült ÁllamokTaking people
  • Veteran Administration Eastern Kansas HealthcareLeavenworth, Egyesült ÁllamokNo longer taking part
  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, Egyesült ÁllamokTaking people
  • Sechler Family Cancer CenterLebanon, Egyesült ÁllamokTaking people
  • University of Kansas Cancer Center - Lee's SummitLee's Summit, Egyesült ÁllamokTaking people
  • Markey Cancer Center at Lexington ClinicLexington, Egyesült ÁllamokTaking people
  • University of Kentucky/Markey Cancer CenterLexington, Egyesült ÁllamokTaking people
  • AMG Libertyville - OncologyLibertyville, Egyesült ÁllamokTaking people
  • Condell Memorial HospitalLibertyville, Egyesült ÁllamokTaking people
  • Trinity Health Saint Mary Mercy Livonia HospitalLivonia, Egyesült ÁllamokTaking people
  • Loma Linda University Medical CenterLoma Linda, Egyesült ÁllamokTaking people
  • Cedars-Sinai Medical CenterLos Angeles, Egyesült ÁllamokTaking people
  • Kaiser Permanente Los Angeles Medical CenterLos Angeles, Egyesült ÁllamokTaking people
  • Kaiser Permanente West Los AngelesLos Angeles, Egyesült ÁllamokTaking people
  • Kaiser Permanente Lutherville - Timonium Medical CenterLutherville, Egyesült ÁllamokTaking people
  • Centra Alan B Pearson Regional Cancer CenterLynchburg, Egyesült ÁllamokTaking people
  • Illinois CancerCare-MacombMacomb, Egyesült ÁllamokTaking people
  • University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, Egyesült ÁllamokTaking people
  • University of Wisconsin Carbone Cancer Center - University HospitalMadison, Egyesült ÁllamokTaking people
  • Solinsky Center for Cancer CareManchester, Egyesült ÁllamokTaking people
  • OhioHealth Mansfield HospitalMansfield, Egyesült ÁllamokTaking people
  • Aurora Bay Area Medical Group-MarinetteMarinette, Egyesült ÁllamokTaking people
  • OhioHealth Marion General HospitalMarion, Egyesült ÁllamokTaking people
  • Marshfield Medical Center-MarshfieldMarshfield, Egyesült ÁllamokTaking people
  • WVUH-Berkely Medical CenterMartinsburg, Egyesült ÁllamokTaking people
  • Fremont - Rideout Cancer CenterMarysville, Egyesült ÁllamokTaking people
  • Mather Veteran Affairs Medical CenterMather, Egyesült ÁllamokTaking people
  • Carle Physician Group-Mattoon/CharlestonMattoon, Egyesült ÁllamokTaking people
  • Loyola University Medical CenterMaywood, Egyesült ÁllamokTaking people
  • UPMC Cancer Center at UPMC McKeesportMcKeesport, Egyesült ÁllamokTaking people
  • Kaiser Permanente Tysons Corner Medical CenterMcLean, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, Egyesült ÁllamokTaking people
  • Baptist Memorial Hospital and Cancer Center-MemphisMemphis, Egyesült ÁllamokTaking people
  • Idaho Urologic Institute-MeridianMeridian, Egyesült ÁllamokTaking people
  • Saint Luke's Cancer Institute - MeridianMeridian, Egyesült ÁllamokTaking people
  • Beebe South Coastal Health CampusMillville, Egyesült ÁllamokTaking people
  • Aurora Cancer Care-MilwaukeeMilwaukee, Egyesült ÁllamokTaking people
  • Aurora Saint Luke's Medical CenterMilwaukee, Egyesült ÁllamokTaking people
  • Aurora Sinai Medical CenterMilwaukee, Egyesült ÁllamokTaking people
  • Abbott-Northwestern HospitalMinneapolis, Egyesült ÁllamokTaking people
  • Community Medical CenterMissoula, Egyesült ÁllamokTaking people
  • Mobile Infirmary Medical CenterMobile, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center - MonroevilleMonroeville, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center in CoraopolisMoon Township, Egyesült ÁllamokTaking people
  • Virtua Samson Cancer CenterMoorestown, Egyesült ÁllamokTaking people
  • West Virginia University HealthcareMorgantown, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center - Part of Frick HospitalMount Pleasant, Egyesült ÁllamokTaking people
  • The Community HospitalMunster, Egyesült ÁllamokTaking people
  • Women's Diagnostic Center - MunsterMunster, Egyesült ÁllamokTaking people
  • Arnold Palmer Cancer Center Medical Oncology NorwinN. Huntingdon, Egyesült ÁllamokTaking people
  • Saint Alphonsus Cancer Care Center-NampaNampa, Egyesült ÁllamokTaking people
  • Saint Luke's Cancer Institute - NampaNampa, Egyesült ÁllamokTaking people
  • UPMC Cancer Center-Natrona HeightsNatrona Heights, Egyesült ÁllamokTaking people
  • Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer Center - New CastleNew Castle, Egyesült ÁllamokTaking people
  • Yale UniversityNew Haven, Egyesült ÁllamokTaking people
  • Cancer Center of Western WisconsinNew Richmond, Egyesült ÁllamokTaking people
  • Helen F Graham Cancer CenterNewark, Egyesült ÁllamokTaking people
  • Medical Oncology Hematology Consultants PANewark, Egyesült ÁllamokTaking people
  • Providence Newberg Medical CenterNewberg, Egyesült ÁllamokNo longer taking part
  • Carle BroMenn Medical CenterNormal, Egyesült ÁllamokTaking people
  • Carle Cancer Institute NormalNormal, Egyesült ÁllamokTaking people
  • Yale-New Haven Hospital North Haven Medical CenterNorth Haven, Egyesült ÁllamokTaking people
  • Cancer Care Center of O'FallonO'Fallon, Egyesült ÁllamokTaking people
  • HSHS Saint Elizabeth's HospitalO'Fallon, Egyesült ÁllamokTaking people
  • Northwestern Medicine Oak BrookOak Brook, Egyesült ÁllamokTaking people
  • Advocate Christ Medical CenterOak Lawn, Egyesült ÁllamokTaking people
  • Advocate Outpatient Center - Oak LawnOak Lawn, Egyesült ÁllamokTaking people
  • Kaiser Permanente-OaklandOakland, Egyesült ÁllamokTaking people
  • Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, Egyesült ÁllamokTaking people
  • Mercy Hospital Oklahoma CityOklahoma City, Egyesült ÁllamokTaking people
  • University of Oklahoma Health Sciences CenterOklahoma City, Egyesült ÁllamokTaking people
  • Integris Southwest Medical CenterOklahoma City, Egyesült ÁllamokNo longer taking part
  • The University of Kansas Cancer Center - OlatheOlathe, Egyesült ÁllamokTaking people
  • Kaiser Permanente-OntarioOntario, Egyesült ÁllamokTaking people
  • Saint Alphonsus Cancer Care Center-OntarioOntario, Egyesült ÁllamokTaking people
  • Providence Willamette Falls Medical CenterOregon City, Egyesült ÁllamokNo longer taking part
  • Northwestern Medicine Orland ParkOrland Park, Egyesült ÁllamokTaking people
  • Lake Regional HospitalOsage Beach, Egyesült ÁllamokTaking people
  • Vince Lombardi Cancer Clinic - OshkoshOshkosh, Egyesült ÁllamokTaking people
  • Illinois CancerCare-Ottawa ClinicOttawa, Egyesült ÁllamokTaking people
  • University of Kansas Cancer Center-Overland ParkOverland Park, Egyesült ÁllamokTaking people
  • University of Kansas Hospital-Indian Creek CampusOverland Park, Egyesült ÁllamokTaking people
  • Baptist Memorial Hospital and Cancer Center-OxfordOxford, Egyesült ÁllamokTaking people
  • VA Palo Alto Health Care SystemPalo Alto, Egyesült ÁllamokTaking people
  • Advocate High Tech Medical ParkPalos Heights, Egyesült ÁllamokTaking people
  • Kaiser Permanente - Panorama CityPanorama City, Egyesült ÁllamokTaking people
  • Advocate Lutheran General HospitalPark Ridge, Egyesült ÁllamokTaking people
  • Camden Clark Medical CenterParkersburg, Egyesült ÁllamokTaking people
  • Lahey Clinic PeabodyPeabody, Egyesült ÁllamokTaking people
  • Illinois CancerCare-PekinPekin, Egyesült ÁllamokTaking people
  • Illinois CancerCare-PeoriaPeoria, Egyesült ÁllamokTaking people
  • Illinois CancerCare-PeruPeru, Egyesült ÁllamokTaking people
  • Fox Chase Cancer CenterPhiladelphia, Egyesült ÁllamokTaking people
  • Temple University HospitalPhiladelphia, Egyesült ÁllamokTaking people
  • University of Pennsylvania/Abramson Cancer CenterPhiladelphia, Egyesült ÁllamokTaking people
  • OhioHealth Pickerington Methodist HospitalPickerington, Egyesült ÁllamokTaking people
  • FirstHealth of the Carolinas-Moore Regional HospitalPinehurst, Egyesült ÁllamokTaking people
  • UPMC Hillman Cancer CenterPittsburgh, Egyesült ÁllamokTaking people
  • UPMC-Passavant HospitalPittsburgh, Egyesült ÁllamokTaking people
  • UPMC-Saint Clair Hospital Cancer CenterPittsburgh, Egyesült ÁllamokTaking people
  • UPMC-Saint MargaretPittsburgh, Egyesült ÁllamokTaking people
  • Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, Egyesült ÁllamokTaking people
  • Kaiser Permanente NorthwestPortland, Egyesült ÁllamokTaking people
  • Oregon Health and Science UniversityPortland, Egyesült ÁllamokTaking people
  • Providence Portland Medical CenterPortland, Egyesült ÁllamokNo longer taking part
  • Providence Saint Vincent Medical CenterPortland, Egyesült ÁllamokNo longer taking part
  • Kootenai Clinic Cancer Services - Post FallsPost Falls, Egyesült ÁllamokTaking people
  • Illinois CancerCare-PrincetonPrinceton, Egyesült ÁllamokTaking people
  • Aurora Cancer Care-RacineRacine, Egyesült ÁllamokTaking people
  • Eisenhower Medical CenterRancho Mirage, Egyesült ÁllamokNo longer taking part
  • Rapid City Regional HospitalRapid City, Egyesült ÁllamokTaking people
  • Beebe Health CampusRehoboth Beach, Egyesült ÁllamokTaking people
  • VCU Massey Cancer Center at Stony PointRichmond, Egyesült ÁllamokTaking people
  • VCU Massey Comprehensive Cancer CenterRichmond, Egyesült ÁllamokTaking people
  • Virginia Cancer InstituteRichmond, Egyesült ÁllamokTaking people
  • Kaiser Permanente-RiversideRiverside, Egyesült ÁllamokTaking people
  • North Memorial Medical Health CenterRobbinsdale, Egyesült ÁllamokTaking people
  • Mayo Clinic in RochesterRochester, Egyesült ÁllamokTaking people
  • University of RochesterRochester, Egyesült ÁllamokTaking people
  • Penobscot Bay Medical CenterRockport, Egyesült ÁllamokTaking people
  • Kaiser Permanente-RosevilleRoseville, Egyesült ÁllamokTaking people
  • Kaiser Permanente Downtown CommonsSacramento, Egyesült ÁllamokTaking people
  • University of California Davis Comprehensive Cancer CenterSacramento, Egyesült ÁllamokTaking people
  • Dartmouth Cancer Center - NorthSaint Johnsbury, Egyesült ÁllamokTaking people
  • Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Egyesült ÁllamokTaking people
  • Regions HospitalSaint Paul, Egyesült ÁllamokTaking people
  • United HospitalSaint Paul, Egyesült ÁllamokTaking people
  • Sainte Genevieve County Memorial HospitalSainte Genevieve, Egyesült ÁllamokTaking people
  • Salem HospitalSalem, Egyesült ÁllamokNo longer taking part
  • Salina Regional Health CenterSalina, Egyesült ÁllamokTaking people
  • Huntsman Cancer Institute/University of UtahSalt Lake City, Egyesült ÁllamokTaking people
  • Kaiser Permanente-San Diego ZionSan Diego, Egyesült ÁllamokTaking people
  • Kaiser Permanente-San FranciscoSan Francisco, Egyesült ÁllamokTaking people
  • Veterans Affairs Medical Center - San FranciscoSan Francisco, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Santa Teresa-San JoseSan Jose, Egyesült ÁllamokTaking people
  • Kaiser Permanente San LeandroSan Leandro, Egyesült ÁllamokTaking people
  • Kaiser Permanente-San MarcosSan Marcos, Egyesült ÁllamokTaking people
  • Mills Health CenterSan Mateo, Egyesült ÁllamokTaking people
  • Kaiser San Rafael-GallinasSan Rafael, Egyesült ÁllamokTaking people
  • Kootenai Clinic Cancer Services - SandpointSandpoint, Egyesült ÁllamokTaking people
  • Essentia Health SandstoneSandstone, Egyesült ÁllamokTaking people
  • MaineHealth Cancer Care Center of York CountySanford, Egyesült ÁllamokTaking people
  • Ridley-Tree Cancer CenterSanta Barbara, Egyesült ÁllamokTaking people
  • Kaiser Permanente Medical Center - Santa ClaraSanta Clara, Egyesült ÁllamokTaking people
  • Gulf Health Hospitals Inc/Infirmary Cancer Care - SaralandSaraland, Egyesült ÁllamokTaking people
  • Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerSavannah, Egyesült ÁllamokTaking people
  • MaineHealth Maine Medical Center- ScarboroughScarborough, Egyesült ÁllamokTaking people
  • UPMC Cancer Center at UPMC NorthwestSeneca, Egyesült ÁllamokTaking people
  • Saint Vincent Hospital Cancer Center at SheboyganSheboygan, Egyesült ÁllamokTaking people
  • Sheboygan Physicians GroupSheboygan, Egyesült ÁllamokTaking people
  • Vince Lombardi Cancer Clinic-SheboyganSheboygan, Egyesült ÁllamokTaking people
  • Memorial Hospital EastShiloh, Egyesült ÁllamokTaking people
  • Sanford Cancer Center Oncology ClinicSioux Falls, Egyesült ÁllamokTaking people
  • Sanford USD Medical Center - Sioux FallsSioux Falls, Egyesült ÁllamokTaking people
  • VCU Community Memorial Health CenterSouth Hill, Egyesült ÁllamokTaking people
  • MaineHealth Cancer Care and IV Therapy - South PortlandSouth Portland, Egyesült ÁllamokTaking people
  • Kaiser Permanente-South San FranciscoSouth San Francisco, Egyesült ÁllamokTaking people
  • Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, Egyesült ÁllamokTaking people
  • Spartanburg Medical CenterSpartanburg, Egyesült ÁllamokTaking people
  • Baystate Medical CenterSpringfield, Egyesült ÁllamokTaking people
  • Southern Illinois University School of MedicineSpringfield, Egyesült ÁllamokTaking people
  • Springfield ClinicSpringfield, Egyesült ÁllamokTaking people
  • Springfield Memorial HospitalSpringfield, Egyesült ÁllamokTaking people
  • Mercy Hospital SouthSt Louis, Egyesült ÁllamokTaking people
  • Missouri Baptist Medical CenterSt Louis, Egyesült ÁllamokTaking people
  • Siteman Cancer Center at Christian HospitalSt Louis, Egyesült ÁllamokTaking people
  • Siteman Cancer Center-South CountySt Louis, Egyesült ÁllamokTaking people
  • Veteran's Affairs Medical Center - Saint LouisSt Louis, Egyesült ÁllamokTaking people
  • Washington University School of MedicineSt Louis, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center at Long RidgeStamford, Egyesült ÁllamokTaking people
  • Marshfield Medical Center-River Region at Stevens PointStevens Point, Egyesült ÁllamokTaking people
  • Stony Brook University Medical CenterStony Brook, Egyesült ÁllamokTaking people
  • Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, Egyesült ÁllamokTaking people
  • Missouri Baptist Sullivan HospitalSullivan, Egyesült ÁllamokTaking people
  • Aurora Medical Center in SummitSummit, Egyesült ÁllamokTaking people
  • ProMedica Flower HospitalSylvania, Egyesült ÁllamokTaking people
  • Moffitt Cancer CenterTampa, Egyesült ÁllamokTaking people
  • Cedars-Sinai Cancer - TarzanaTarzana, Egyesült ÁllamokTaking people
  • James J Peters VA Medical CenterThe Bronx, Egyesült ÁllamokTaking people
  • Montefiore Medical Center-Einstein CampusThe Bronx, Egyesült ÁllamokTaking people
  • University of Kansas Health System Saint Francis CampusTopeka, Egyesült ÁllamokTaking people
  • City of Hope South BayTorrance, Egyesült ÁllamokTaking people
  • Torrance Memorial Physician Network - Cancer CareTorrance, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital-Torrington Care CenterTorrington, Egyesült ÁllamokTaking people
  • Upper Valley Medical CenterTroy, Egyesült ÁllamokTaking people
  • Gene Upshaw Memorial Tahoe Forest Cancer CenterTruckee, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center-TrumbullTrumbull, Egyesült ÁllamokTaking people
  • Banner University Medical Center - TucsonTucson, Egyesült ÁllamokTaking people
  • University of Arizona Cancer Center-North CampusTucson, Egyesült ÁllamokTaking people
  • Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, Egyesült ÁllamokTaking people
  • SMC Center for Hematology Oncology UnionUnion, Egyesült ÁllamokTaking people
  • UPMC Cancer Center-UniontownUniontown, Egyesült ÁllamokTaking people
  • City of Hope UplandUpland, Egyesült ÁllamokTaking people
  • Carle Cancer CenterUrbana, Egyesült ÁllamokTaking people
  • Kaiser Permanente-VallejoVallejo, Egyesült ÁllamokTaking people
  • Northwest Cancer Center - ValparaisoValparaiso, Egyesült ÁllamokTaking people
  • Essentia Health Virginia ClinicVirginia, Egyesült ÁllamokTaking people
  • Virtua VoorheesVoorhees Township, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Walnut CreekWalnut Creek, Egyesült ÁllamokTaking people
  • Northwestern Medicine Cancer Center WarrenvilleWarrenville, Egyesült ÁllamokTaking people
  • Illinois CancerCare - WashingtonWashington, Egyesült ÁllamokTaking people
  • UPMC Cancer Center-WashingtonWashington, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Capitol Hill Medical CenterWashington D.C., Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital-Waterbury Care CenterWaterbury, Egyesült ÁllamokTaking people
  • Smilow Cancer Hospital Care Center - WaterfordWaterford, Egyesült ÁllamokTaking people
  • Aurora Cancer Care-Milwaukee WestWauwatosa, Egyesült ÁllamokTaking people
  • Wilmot Cancer Institute at WebsterWebster, Egyesült ÁllamokTaking people
  • Aurora West Allis Medical CenterWest Allis, Egyesült ÁllamokTaking people
  • Veterans Affairs Connecticut Healthcare System-West Haven CampusWest Haven, Egyesült ÁllamokTaking people
  • Good Samaritan University HospitalWest Islip, Egyesült ÁllamokTaking people
  • OhioHealth Westerville Medical Campus/Westerville Cancer CenterWesterville, Egyesült ÁllamokTaking people
  • Marshfield Medical Center - WestonWeston, Egyesült ÁllamokTaking people
  • University of Kansas Hospital-Westwood Cancer CenterWestwood, Egyesült ÁllamokTaking people
  • Wheeling Hospital/Schiffler Cancer CenterWheeling, Egyesült ÁllamokTaking people
  • White River Junction Veteran Administration Medical CenterWhite River Junction, Egyesült ÁllamokTaking people
  • Presbyterian Intercommunity HospitalWhittier, Egyesült ÁllamokNo longer taking part
  • Divine Providence HospitalWilliamsport, Egyesült ÁllamokTaking people
  • UPMC SusquehannaWilliamsport, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Caton Hill Medical CenterWoodbridge, Egyesült ÁllamokTaking people
  • Minnesota Oncology Hematology PA-WoodburyWoodbury, Egyesült ÁllamokTaking people
  • Kaiser Permanente-Woodland HillsWoodland Hills, Egyesült ÁllamokTaking people
  • UMass Memorial Medical Center - University CampusWorcester, Egyesült ÁllamokTaking people
  • Sanford Cancer Center WorthingtonWorthington, Egyesült ÁllamokTaking people
  • Cancer Care Associates of YorkYork, Egyesült ÁllamokNo longer taking part
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, Egyesült ÁllamokTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
SWOG Cancer Research Network
Trial code
NCT06616584
Record updated
2026. október 9.
Original description
This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel and ramucirumab alone in treating patients with non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Cemiplimab is a monoclonal antibody that stimulates the immune system by blocking the PD-1 pathway. Tumors use the PD-1 pathway to escape attacks from the immune system. By blocking the PD-1 pathway, cemiplimab may help the immune system recognize and attack tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Adding cemiplimab to usual treatment, docetaxel and ramucirumab, may kill more tumor cells compared to docetaxel and ramucirumab alone in treating patients with stage IV or recurrent non-small cell lung cancer.Read full original descriptionShow less

A Randomized Phase II/III Study of Docetaxel and Ramucirumab With or Without Cemiplimab for Participants Previously Treated With Platinum-Based Chemotherapy and Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer (Lung-MAP Non-Matched Sub-Study)

This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel and ramucirumab alone in treating patients with non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Cemiplimab is a monoclonal antibody that stimulates the immune system by blocking the PD-1 pathway. Tumors use the PD-1 pathway to escape attacks from the immune system. By blocking the PD-1 pathway, cemiplimab may help the immune system recognize and attack tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Adding cemiplimab to usual treatment, docetaxel and ramucirumab, may kill more tumor cells compared to docetaxel and ramucirumab alone in treating patients with stage IV or recurrent non-small cell lung cancer.

Inclusion: Participants must have been assigned to S1800E by the Southwest Oncology Group (SWOG) Statistics and Data Management Center (SDMC). Assignment to S1800E is determined by the LUNGMAP protocol; Participants must have measurable or non-measurable disease documented by CT or MRI. The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to randomization. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to randomization. All disease must be assessed and documented on the Baseline Tumor Assessment Form. Participants whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to registration; Participants must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to randomization; Participants must have received exactly one anti-PD-1 or anti-PD-L1 therapy for advanced disease (stage IV or recurrent disease, or stage I-III disease in certain circumstances outlined below). Anti-PD-1 or anti-PD-L1 therapy may have been given alone or in combination with other therapy. For participants who received neoadjuvant, adjuvant, and/or consolidation anti-PD-1 or anti-PD-L1 therapy for stage I-III disease:; If they experienced disease progression within (≤) 365 days from initiation (cycle 1 day 1) or anti-PD-1 or anti-PD-L1 therapy, this counts as the single allowed anti-PD-1 or anti-PD-L1 therapy for advanced disease; If they experienced disease progression more than (>) 365 days from initiation (cycle 1 day 1) or anti-PD-1 or anti-PD-L1 therapy, this is not considered anti-PD-1 or anti-PD-L1 therapy for advance disease. These participants must have received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease; Participants must have experienced disease progression (in the opinion of the treating investigator) more than (>) 84 days following initiation (cycle 1 day 1) of their most recent anti-PD-1 or anti-PD-L1 therapy; Participants who received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease must have had a best response of stable disease, partial response or complete response (in the opinion of the treating investigator) on the anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease; Participants must have received platinum-based chemotherapy and experienced disease progression (in the opinion of the treating investigator) during or after this regimen; Participants with a known sensitizing molecular alteration for which a Food and Drug Administration (FDA)-approved targeted therapy for NSCLC exists (e.g., EGFR, ALK, ROS1, BRAF, RET, NTRK, KRAS, HER2, and MET sensitizing mutations), must have previously received at least one of the approved therapy(s). Prior targeted therapy for participants with targetable alterations is allowed if all other eligibility criteria are also met; Participants must have recovered (≤ grade 1) from any side effects from the most recent anti-cancer treatment prior to randomization; Participants must not have received prior therapy with docetaxel for this disease; Participants must not have received any palliative radiation therapy within 14 days (or palliative bone radiation therapy within 7 days) prior to randomization; Participants must not be planning to receive any concurrent chemotherapy, immunotherapy, or biologic therapy for cancer treatment while receiving treatment on this study; Participants must not have undergone major surgery within 28 days prior to randomization, or subcutaneous venous access device placement within 7 days prior to randomization. Participants must not have postoperative bleeding complications or wound complications from a surgical procedure performed within 2 months prior to randomization. The participant must not have elective or planned major surgery to be performed during the course of this study; Absolute neutrophil count ≥ 1.5 x 10\^3/uL (within 28 days prior to randomization); Hemoglobin ≥ 9.0 g/dL (within 28 days prior to randomization); Platelets ≥ 100 x 10\^3/uL (within 28 days prior to randomization); Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (within 28 days prior to randomization) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin ≤ 5 x institutional ULN; Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN (within 28 days prior to randomization). Participants with history of liver metastasis must have AST and ALT ≤ 5 x ULN; Participants must have a creatinine ≤ the institutional (I)ULN or calculated creatinine clearance ≥ 50 mL/min using the following Cockcroft-Gault formula. This specimen must have been drawn and processed within 28 days prior to randomization; Participants must have a urinary protein test performed within 28 days prior to randomization; Participants' most recent Zubrod/Eastern Cooperative Oncology Group (ECOG) performance status must be 0-1 and be documented within 28 days prior to randomization; Participants must have a completed medical history and physical exam within 28 days prior to randomization; Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load while on suppressive therapy on the most recent test results obtained within 6 months prior to randomization, if indicated by the treating investigator; Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants currently being treated for HCV infection must have undetectable HCV viral load test on the most recent test results obtained within 6 months prior to randomization, if indicated by the treating investigator; Participants with known human immunodeficiency virus (HIV) infection are eligible, provided they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to randomization; Participants must not have a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen; Participants must not have an active autoimmune disease that has required systemic treatment within 730 days prior to randomization (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed; Participants must not have any history of primary immunodeficiency; Participants must be able to safely receive study therapy and must not have experienced the following:; Any grade 3 or worse immune-mediated adverse event. Exception: asymptomatic nonbullous/nonexfoliative rash; Any unresolved grade 2 immune-mediated adverse event; Any toxicity that led to permanent discontinuation of prior anti-PD-1/PD-L1 immunotherapy; Exception to the above: Toxicities of any grade that requires replacement therapy and has stabilized on therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) are allowed; Participants must not have any history of organ transplant that requires use of immunosuppressives; Participants must not have received a live or live attenuated vaccine within 28 days prior to randomization. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever rabies, Bacillus Calmette-Guerin (BCG) and typhoid vaccine. Seasonal influenza vaccines and COVID-19 vaccines are allowed, however, intranasal influenza vaccines (e.g. Flu-Mist) are live attenuated and are not allowed; Participants must not have clinical signs or symptoms of active tuberculosis infection; Participants must not have a history of (non-infectious) pneumonitis that required steroids or current pneumonitis/interstitial lung disease; Participants must not have had a serious or nonhealing wound, ulcer, or bone fracture within 28 days prior to randomization; Participants must not have a history of gastrointestinal perforation or fistula within 6 months prior to randomization; Participants must not have grade 3-4 gastrointestinal bleeding (defined by National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] version [v]5) within 3 months prior to randomization. No history of gastrointestinal (GI) bleed within 3 months prior to randomization; Participants must not have any grade III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., participants with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months prior to randomization, or serious uncontrolled cardiac arrhythmia; Participants must not have experienced any arterial thromboembolic events, including but not limited to myocardial infarction, transient ischemic attack, cerebrovascular accident, or unstable angina, within 6 months prior to randomization; Participants must not have gross hemoptysis within two months prior to randomization (defined as bright red blood or ≥ 1/2 teaspoon) or with radiographic evidence of intratumor cavitation or has radiologically documented evidence of major blood vessel invasion or encasement by cancer; Participants must not have been diagnosed with venous thrombosis within 3 months prior to randomization. Participants with venous thrombosis diagnosed more than 3 months prior to randomization must be on stable doses of anticoagulants; Participants must not have cirrhosis at a level of Child-Pugh B (or worse) AND a history of hepatic encephalopathy or clinically meaningful ascites resulting from cirrhosis, OR any degree of cirrhosis; Participants must not be pregnant or breastfeeding (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped). Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen; Participants must agree to have blood specimens submitted for circulating tumor DNA (ctDNA); Participants must be offered participation in specimen banking. With participant consent, specimens must be collected and submitted via the SWOG specimen tracking system; NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system; Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. NOTE: Participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations.

ClinicalTrials.gov NCT06616584