The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the rGBM

Korábbi kezelés

• Severe concurrent diseases in the heart, lungs, liver, or other vital organs;
• Long-term use of immunosuppressant drugs, or large doses of steroids;

Más betegség

• Known allergies to study drugs or drugs that may be used in the study;
• Hypertension is poorly controlled or accompanied by hypertensive crisis or hypertensive encephalopathy;
• In addition to the glioblastoma, with other severe central nervous system diseases or complications or aggressive malignancies;

Laborértékek

• Received live or attenuated vaccine or other surgery had no related to GBM within 4 weeks prior to Lymphocytes apheresis;
• Lymphocytes apheresis or cell infusion combined with infection or unexplained fever.

• Age ≥18，both sexes;
• Diagnosed with a history of glioblastoma, and the recurrent glioblastoma has confirmed by histological/molecular pathology (including astrocytoma World Health Organization (WHO) Grade 4);
• Karnofsky (KPS) ≥50;
• The estimated survival time is ≥12 weeks;
• Blood pregnancy tests for women of childbearing age are negative;
• The patient himself/herself, and/or his/her legal guardian, agree to participate in the trial and sign the informed consent form.