Lipoprotein (a) and Vascular Regenerative Cell Content

Korábbi kezelés

• Any malignancy not considered cured (except basal cell carcinoma of the skin). An individual is considered cured if there has been no evidence of cancer recurrence for the five years prior to screening.
• Previously received ribonucleic acid therapy specifically targeting Lp(a).
• On oral steroid therapy (e.g., prednisone or other corticosteroids) or other immunosuppressive agents (e.g., methotrexate).

Más betegség

• Any life-threatening disease expected to result in death within two years of consent.
• Uncontrolled hypertension.
• New York Heart Association Class IV heart failure.
• Active liver disease or liver dysfunction.
• Active kidney disease or kidney dysfunction.
• History of hemorrhagic stroke or other major bleeding disorder.
• Active infectious disease requiring systemic antibiotic or anti-viral agents.
• Known acquired immunodeficiency syndrome, such as human immunodeficiency virus.
• Treated autoimmune disorders.

Laborértékek

• White blood cell count ≥15 x 10\^9/L.

Egyéb

• Unable or unwilling to provide written informed consent or provide a peripheral blood sample.
• Women who are pregnant or nursing.
• Participating in another study/trial that is likely to affect the primary outcome.

• Adults ≥18 years of age and ≤80 years of age who meet either of the following criteria:
  • Elevated Lp(a) (defined as greater than or equal to 100 nmol/L)
  • Non-elevated Lp(a) (defined as less than 100 nmol/L)
• Willing and able to provide written informed consent and comply with study procedures.