HAIC in Combination With PD-1 Inhibitors and Lenvatinib for High Tumor Burden Advanced HCC (CHANCE2416)

Korábbi kezelés

• Patients who took anti-tumor treatments before the combination therapy;

Más betegség

• With other malignant tumors;

Egyéb

• incomplete data.

• Age 18 to 80 years old;
• Diagnosis of HCC was confirmed by histologic or cytologic analysis or clinical features according to the American Association for the Study of Liver Diseases (AASLD) guideline;
• At least one measurable intrahepatic lesion as per the RECIST 1.1 criteria;
• HCC staging of the patients are consistent with both the BCLC stage C and the CNLC stage IIIa.
• Presence of PVTT;
• Patients received a first-line lenvatinib+PD-1 (L+P) inhibitors combination or that of HAIC+lenvatinib+PD-1 inhibitors (H+L+P). More specifically, the administration of lenvatinib was concomitant with PD-1 inhibitors, and HAIC was performed either concurrently with, or up to 2 months before or after the L+P inhibitors combination therapy. Patients in the H+L+P group should undergo at least 2 cycles of HAIC, receive at least 2 cycles of PD-1 inhibiors and take at least 2 months of lenvatinib. Patients in the L+P group should receive at least 2 cycles of PD-1 inhibiors, and take at least 2 months of lenvatinib.
• Child-Pugh class A or B7;
• Tumor burden meets up to 7 out criteria.