A 12-week Pilot Nutrition Intervention for Children With New Diagnosis of Stage 3 Type 1 Diabetes (T1D)

Korábbi kezelés

• Concurrent or recent (within the past 30 days of screening) use of non-insulin therapies to control hyperglycemia including immunosuppressive therapies
• Prior diagnosis or positive screening of food sensory disorders

Más betegség

• Chronic inflammatory or autoimmune diseases with exception of stable autoimmune thyroid disease
• Diagnosis of celiac disease or being actively evaluated for possible celiac disease, inflammatory bowel disease or any underlying illness cause acute or chronic intestinal malabsorption.
• Food allergies (nuts, soy, seafood, milk-protein, or as deemed by the principal investigator) that are a barrier for consumption of a balanced diet that meets nutrient requirements
• Any condition that, in the investigator's opinion, may compromise study participation or may confound the interpretation to the study results

Laborértékek

• Use of medications known to influence glucose intolerance within 30 days of T1D diagnosis

Egyéb

• Children with new diagnosis of T1D who are not metabolically stable (E.g. acute dehydration, severe hyperglycemia with moderate/large ketones at the time of the enrollment visit)
• Children requiring enteral feeds or parenteral nutrition support
• Use of glucocorticoids or other immunosuppressive agents within 30 days of T1D diagnosis

• Willing and able to give assent and to have a parent or legal guardian to provide informed consent
• Less or equal than 60 days from T1D diagnosis based on American Diabetes Association criteria, and metabolically stable per study physician assessment
• Boys and girls (Any Tanner stage), 6-17 years of age, at time of enrollment visit
• Evidence of at least one positive T1D autoantibody (excluding insulin antibodies in those who have received ≥ 2 weeks of exogenous insulin therapy) either through clinically obtained labs at time of diagnosis or as obtained at the screening visit
• Children with new diagnosis of T1D need to be established patients from Penn State Health- Pediatric diabetes clinic at the time of the enrollment visit
• Capability to eat different types of food by mouth
• Daily use of a 24-hour continuous glucose monitor by the time of the enrollment visit
• Willing and being able to give assent and have a parent or legal guardian provide informed consent