Black Barley Study - Barley to Support Food and Drink Innovation (RI-B7-3)
Key facts
- Where
- Aberdeen, Egyesült KirályságSee the site
Where in Egyesült Királyság
- University of Aberdeen, The Rowett InstituteAberdeen, Egyesült KirályságNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Aberdeen
- Trial code
- NCT06673212
- Record updated
- 2024. november 12.
- Original description
Sustained postprandial hyperglycaemia is an independent risk factor for cardiovascular complications and death. Intensive glucose control is the predominant factor to prevent the development of chronic complications in Type 2 Diabetes Mellitus (T2DM). The investigators have shown that phytochemical-rich extracts (in this case anthocyanins and their derivatives) can attenuate glucose response and there is also strong evidence for the role of fibre. Here a selected barley line (rich in anthocyanins and (1,3;1,4)-β-glucan) will be compared to a control barley and control wheat in an acute human dietary intervention (with n=15 healthy volunteers) to explore the potential to modulate postprandial glycaemia and insulinaenemia. An additional secondary outcome will include metabolomics analysis of the blood plasma and urine to detect differences in bioactive compounds including phytochemical metabolites. This will help ensure that barley lines being bred for human food can also deliver benefits for health.Read full original descriptionShow less
Barley to Support Food and Drink Innovation (RI-B7-3)
Sustained postprandial hyperglycaemia is an independent risk factor for cardiovascular complications and death. Intensive glucose control is the predominant factor to prevent the development of chronic complications in Type 2 Diabetes Mellitus (T2DM). The investigators have shown that phytochemical-rich extracts (in this case anthocyanins and their derivatives) can attenuate glucose response and there is also strong evidence for the role of fibre. Here a selected barley line (rich in anthocyanins and (1,3;1,4)-β-glucan) will be compared to a control barley and control wheat in an acute human dietary intervention (with n=15 healthy volunteers) to explore the potential to modulate postprandial glycaemia and insulinaenemia. An additional secondary outcome will include metabolomics analysis of the blood plasma and urine to detect differences in bioactive compounds including phytochemical metabolites. This will help ensure that barley lines being bred for human food can also deliver benefits for health.
Inclusion: Apparently healthy male and female subjects with Diabetes Risk Score ≥ 7 points.
Exclusion: Type 1 diabetes; Type 2 diabetes controlled with medication; Coeliac Disease; Eating disorders (anorexia, bulimia, binge eating or night eating syndrome); Food allergies/intolerances; Any significant health issues; Breastfeeding/ Pregnancy; Addiction to any substances; Are unable to give written informed consent.