Identification Of High-risk Coronary Plaques By Multimodal Intravascular Imaging

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• Exclusion criteria for the clinical study:
  • Cardiogenic shock or hemodynamic instability;
  • History of coronary artery bypass grafting (CABG), or planned CABG;
  • Severe renal impairment (glomerular filtration rate <30ml/min/1.73m²);
  • Life expectancy of less than 2 years;
  • Currently participating in other ongoing investigative device or drug studies that have not yet reached their primary endpoints.

Egyéb

• Imaging exclusion criteria:
  • The anatomical structure of the non-culprit lesion is not suitable for intravascular imaging catheter imaging (lesions at the left main trunk or right coronary artery ostium, severe calcification, chronic total occlusion, etc.).

• Inclusion criteria for the clinical study:
  • Aged ≥18 years at enrollment, male or female;
  • Meets the diagnosis of acute coronary syndrome, including acute myocardial infarction and unstable angina. Acute myocardial infarction includes ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (non-STEMI). STEMI is defined as chest pain lasting at least 30 minutes, arriving at the hospital within 12 hours from the onset of symptoms, changes in the 12-lead ECG (ST-segment elevation >0.1 mV in ≥2 consecutive leads or new left bundle branch block), and elevated cardiac biomarkers (troponin T/I). Non-STEMI is defined as ischemic symptoms without ST-segment elevation on ECG, accompanied by elevated cardiac biomarkers. Unstable angina is defined as chest pain lasting 5-30 minutes at rest, or worsening of exertional angina, and accompanied by one of the following: transient ST-segment depression or elevation; coronary angiography showing luminal narrowing ≥90% or plaque rupture or thrombotic lesions.
  • Planned to undergo coronary angiography and PCI treatment;
  • Hemodynamically stable and able to tolerate repeated intracoronary administration of nitroglycerin;
  • Capable of understanding the requirements of this study, willing to participate in the study, and have signed an informed consent form.
• Imaging inclusion criteria:
  • Coronary angiography clearly shows that the patient has at least one non-culprit lesion with a visual assessment of diameter stenosis between 40-70%, and the operator believes that interventional treatment intervention is not temporarily necessary;
  • The site of the non-culprit lesion has not previously had a stent implanted.