Tezepelumab in the Treatment of Emergency Room Asthma in Adults (TERAA)

Korábbi kezelés

• Previous enrolment in the present study
• Participation in another clinical study with an investigational product during the last 6 months
• Any concomitant medications that are known to be associated with Torsades de Pointes or potent inducers of cytochrome P450 3A4 (CYP3A4).

Más betegség

• Patients with a known hypersensitivity to Tezepelumab or any of the excipients of the product.
• Positive hepatitis C antibody hepatitis B virus surface antigen or hepatitis B virus core antibody, at screening.
• Current smokers with a smoking history of > 10 pack-years. Current smokers with a smoking history of < 10 pack-years are permitted . Ex-smokers should not have a smoking history > 10 pack-years at screening. Participants who use e-cigarettes will also be excluded from the study.
• Known history of drug or alcohol abuse within 1 year of screening
• History of arrhythmia (multifocal premature ventricular contractions, bigeminy, trigeminy, ventricular tachycardia), which is symptomatic or requires treatment (CTCAE Grade 3), symptomatic or uncontrolled atrial fibrillation despite treatment, or asymptomatic sustained ventricular tachycardia. Subjects with atrial fibrillation controlled by medication are permitted.

Laborértékek

• History of QT prolongation associated with other medications that required discontinuation of that medication.
• Congenital long QT syndrome.
• Creatinine clearance <50 ml/min (calculated by Cockcroft-Gault formula, reference Appendix G).

Egyéb

• Involvement in the planning and/or conduct of the study (applies to both Investigator staff and/or staff at the study site)
• Patients who are admitted to hospital at screening.
• Known to have tested positive for human immunodeficiency virus
• For women only - currently pregnant (confirmed with positive pregnancy test) or breast feeding.

• Provision of informed consent prior to any study specific procedures
• Female and/or male aged 18 to 55 years
• History of physician-diagnosed asthma
• All subjects will have been prescribed high dose inhaled corticosteroid (> 500 ug fluticasone propionate dry powder formulation equivalents total daily dose. See Appendix C) plus at least one second controller (LABA, LAMA or LTRA) for at least 3 months prior to enrolment.
• Documented history of at least one moderate or severe asthma exacerbation in the past 12 months
• Negative pregnancy test (urine or serum) for female subjects of childbearing potential.
• Female subjects must be 1 year post-menopausal, surgically sterile, or using an acceptable method of contraception (an acceptable method of contraception is defined as a barrier method in conjunction with a spermicide) for the duration of the study (from the time they sign consent) and for 3 months after the last dose of study drug/matching placebo to prevent pregnancy. In addition, oral contraceptives, approved contraceptive implant, long-term injectable contraception, intrauterine device, or tubal ligation are allowed. Oral contraception alone is not acceptable; additional barrier methods in conjunction with spermicide must be used.
• Subjects who are blood donors should not donate blood during the study and for 3 months following their last dose of study drug.
• Subject willing and able to comply with study procedures