RCT Study on the Therapeutic Effect of Escitalopram Loaded With XingpiJieyu Formula on Resting State EEG Energy Abnormalities in Severe Liver Depression and Spleen Deficiency Type MDD

Korábbi kezelés

• Any current or previous mental disorder other than MDD according to DSM-5;
• Drinking alcohol in the week prior to the enrollment;

Más betegség

• Diagnosis of syndromes other than depression and liver-stagnation and spleen-deficiency in the "Guidelines for Diagnosis and Treatment of Internal Diseases in Traditional Chinese Medicine" issued by the China Association of Chinese Medicine in 2008;
• Patients with neurological disorders, somatic disorders, organic brain diseases, and tumour;
• Sleep disorders other than insomnia disorders currently diagnosed according to DSM-5, such as obstructive sleep apnea syndrome, periodic limb movement disorder, restless legs syndrome, etc.

Egyéb

• Suicidal ideation or suicidal behaviour (HAMD-17 item 3 > 2);

• outpatient/inpatient, age 18-45 years old, right-handed;
• western medical diagnosis meets the diagnostic criteria of MDD in DSM-5, without psychiatric features;
• In accordance with the diagnostic criteria of depression and liver-stagnation and spleen-deficiency in the "Guidelines for Diagnosis and Treatment of Internal Diseases in Traditional Chinese Medicine" issued by the China Association of Chinese Medicine in 2008;
• 17-item Hamilton Depression Scale score ≥18;
• educational experience ≥5 years;
• The current episode has not used antidepressants, antipsychotics, mood stabilizers, or other medications that can act on the central nervous system for at least 4 weeks;
• Have not received physical therapy, such as MECT, rTMS, etc., in the past 6 months;
• The total duration of the disease ≤10 years.