Personalized DBS Targeting for Treating Depression

Korábbi kezelés

• Persons with a history of substance abuse within 12 months; persons with a previous history of epilepsy, and persons with febrile convulsions in childhood;
• Contraindications to DBS surgery and MRI;

Más betegség

• Persons with severe or unstable cardiac, hepatic, renal, endocrine, hematologic, and other medical disorders and co-morbidities with psychotic symptoms, including personality disorders diagnosed by history, questioning, and clinical examination;
• Persons with psychiatric disorders other than depression (except generalized anxiety);
• Patients with a history of suicide attempts within the past 6 months or more than 2 suicide attempts within the past 2 years;

Egyéb

• Women who are breastfeeding, pregnant, and patients who are pregnant or intend to become pregnant during the clinical study;
• Years of education less than or equal to 9 years;
• Patients who are involuntarily hospitalized.

• A psychiatrist-confirmed diagnosis of major depressive disorder in accordance with the Diagnostic And Statistical Manual Of Mental Disorders.5th Ed (DSM-V);
• A psychiatric examination by two trained psychiatrists and a diagnosis consistent with the DSM-V;
• A history of depression of at least 12 months duration in depressed patients (including MECT) who have failed to respond to a full dose and course of treatment with 2 or more antidepressants of different mechanisms;
• A 17-item score on the HAMD scale ⩾ 20 at initial screening;
• A score of ≤ 50 on the Gross Assessment of Functioning (GAF) scale;
• The patient himself/herself or legal guardian was able to fully understand the therapy and agreed to enroll after signing an informed consent form.