Stress and Pain in People Living With HIV

Korábbi kezelés

• medications with known central effects on HPA axis and cytokines/immune function

Más betegség

• current use or past history of cocaine or opioid use disorder
• history of any psychotic disorder
• current diagnoses of bipolar disorder and PTSD
• significant underlying medical conditions such as cerebral, renal, thyroid or cardiac pathology that would interfere with study participation

Egyéb

• meet primary, current moderate and severe criteria for other SUD including cocaine, alcohol, opiates, sedatives, nicotine
• psychotic or otherwise severely psychiatrically disabled (i.e., suicidal, homicidal, current mania)
• women who are pregnant, nursing or those using hormonal birth control that affect HPA axis cortisol responses.

• good health as verified by screening examination
• Able to read English and complete study evaluations and provide informed written and verbal consent. Additional criteria PLWH
• HIV-1 lab test positive
• undetectable viral load
• good ART adherence
  • Additional criteria by group:
  • PLWH +CM:
• CB positive urine toxicology
• meet DSM-5 criteria for CUD and MDD as assessed using SCID-I. HC
• HIV-1 test negative
• urine toxicology negative
• no major medical and psychiatric diagnoses based on DSM-V.
  • PLWH Only:
• HIV-1 test positive
• urine toxicology negative
• no major medical and psychiatric diagnoses based on DSM-V.
  • CM Only:
• HIV-1 test negative
• urine toxicology positive
• meet DSM-5 criteria for CUD and MDD as assessed using SCID-I