Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy

Korábbi kezelés

• History of prior myocardial infarction with transmural scar > 50% (based on prior imaging or clinical history).
• Contraindications to MRI (e.g., metallic implants, claustrophobia), SPECT MPI, or FDG-PET.

Más betegség

• History of coronary artery disease, diabetes, or other medical conditions deemed exclusionary by the study team.

Laborértékek

• Patient not eligible for 3T MRI (Any condition or device precluding safe MRI e.g., pacemakers, defibrillators, metal implants), SPECT (significant arrhythmias or hemodynamic instability), or FDG-PET (e.g., severely impaired glucose metabolism).
• Severe renal impairment (GFR < 30 mL/min) or contraindication to FDG PET tracer.
• History of uncontrolled diabetes mellitus (HbA1c > 9%) or inability to achieve stable glucose levels for FDG PET preparation.

Életkor

• Male or female, age < 18 or > 80 years of age. Patients not scheduled for CABG or those without confirmed coronary artery disease (CAD).

Egyéb

• Positive pregnancy test or females currently breastfeeding (on the day of scanning).
• Healthy Volunteer Cohort
• Positive pregnancy test or females currently breastfeeding (on the day of scanning).

• Male or Female, age 18-80 years. Patient scheduled for Coronary Artery Bypass Surgery as standard of care therapy per clinical guidelines.
• Presence of 1 or more stenotic coronary artery vessels. Left Ventricular Ejection Fraction (LVEF) ≤ 40%, or clinical indication for myocardial viability assessment.
• Able to tolerate FDG PET/MRI protocol and preparation (e.g., fasting state, glucose regulation).
• Medication use within 24 hours of the scan is allowed and will be reported. Negative pregnancy test for females of childbearing age (on the day of scanning).
• No known contraindications to 3T MRI, SPECT MPI, or FDG PET.
• Male or Female, age 18-80 years. No history of coronary artery disease or diabetes. Eligible for 3T MRI, SPECT, and FDG-PET. Negative pregnancy test for females of childbearing age (on the day of scanning).

A regiszterben nem jelölt feltételek

• Study Population Description The study population will consist of 12 to 15 human subjects divided into two main groups. The first group includes 6 healthy individuals with a normal left ventricular ejection fraction (LVEF > 0.50). The second group comprises 9 patients with advanced ischemic cardiomyopathy (ICM) and a low LVEF (< 0.40) who are scheduled for standard-of-care Coronary Artery Bypass Graft (CABG) surgery. The study team will aim to recruit a mixed-sex, age-matched population with equal numbers for all metabolic imaging studies.
• Ischemic Cardiomyopathy (ICM) Patient Cohort