Implementation of Machine Learning and Hemodynamic Profiles Based Clinical Decision Support Systems for Personalized Guideline Accordant Antihypertensive Regimens in Primary Care: a Pragmatic Cluster Randomized Controlled Trial

Korábbi kezelés

• Intolerance to 2 or more classes of A, C,D antihypertensive medications.
• Currently taking antihypertensive medications other than class A,B,C and D.
• Reluctant to take antihypertensive medications or have poor compliance with previous treatment.

Más betegség

• Physician-diagnosed or suspected secondary hypertension (e.g., hypertension caused by renal disease, renal artery stenosis, aortic stenosis, primary aldosteronism, pheochromocytoma/paraganglioma, Cushing's syndrome, thyroid dysfunction, intracranial disease, drug-induced, or rare monogenic genetic disease).
• Suspected or diagnosed white coat hypertension.
• History of coronary heart disease.
• History of heart failure.
• Serious medical conditions (e.g., malignant cancer and hepatic dysfunction)
• Currently in an acute episode of disease (e.g, new-onset cardiovascular and cerebrovascular disease occurred within 3 months).
• Cognitive or communicative disorders.

Laborértékek

• Diagnosed chronic kidney disease, estimating Glomerular Filtration Rate (eGFR)< 60 ml/min·1.73m2, or receiving dialysis.

Egyéb

• SBP ≥180mmHg and/or DBP ≥110mmHg at the screening visit.
• Currently pregnant or breastfeeding or planning a pregnant or breastfeeding during the study.
• Participating in other clinical trials.

• 35 ≤ Age < 80 years.
• Regularly attend the clinic for hypertension treatment during the study period, without plans of traveling during the study period.
• Diagnosed with hypertension, with SBP ≥140mmHg at screening.
• Currently taking 0 or 2 classes of antihypertensive medications (A/C/D), with or without concurrent use of class B.
• Willing to participate in the trial and capable of providing written informed consent.