FITting Non-invasive Tests in Lynch Syndrome Surveillance

Korábbi kezelés

• Individuals who have previously undergone a subtotal or total colectomy.

Más betegség

• Individuals with inflammatory bowel disease or active malignancy.

Életkor

• Newly diagnosed Lynch Syndrome patients < 20 years old with a pathogenic variant in MLH1, MSH2 or EPCAM, MSH6 or PMS2.
• Newly diagnosed Lynch Syndrome patients < 30 years old with a pathogenic variant in MSH6 or PMS2.

Egyéb

• Individuals who have not proceeded with genetic testing and therefore are not known to have LS, despite family history and/or criteria for testing.
• Individuals who are pregnant.
• Individuals not willing or able to sign informed consent.

• Have a diagnosis of LS with a confirmed pathogenic variant in MLH1, MSH2, MSH6, PMS2 or EPCAM genes.
• Aged 20 - 80 years (for those with pathogenic variants in MLH1, MSH2, and EPCAM)
• Aged 30 - 80 years (for those with pathogenic variants in PMS2 or MSH6).
• Have an upcoming standard of care (SOC) colonoscopy appointment in line with standard LS surveillance guidelines (NCCN).
• Patients with previous colon surgery who still have 20cm or more of colon remaining
• Patients who are diagnosed with advanced neoplasia (e.g., advanced adenomas or cancers) and have NOT had endoscopic or surgical resection
• Willing to sign informed consent, collect stools samples and complete surveys