Weight Gain Prevention in Adolescents and Young Adults

Korábbi kezelés

• Current or recent (<6 months prior to screening) use of anti-obesity medication(s) or other weight-altering medication(s) (e.g. atypical anti-psychotics, attention deficit hyperactivity disorder (ADHD) stimulant)
• Previous bariatric surgery
• Current or recent (<6 months prior to screening) use of medication(s) to treat insulin resistance
• Recent initiation (<3 months prior to screening) of anti-hypertensive or lipid medication(s)
• Current or recent (<14 days prior to screening) use of monoamine oxidase inhibitor
• History of treatment with growth hormone

Más betegség

• Diabetes (type 1 or 2)
• History of glaucoma
• Known hypersensitivity to sympathomimetic amines
• Eating disorder symptoms within 6 months and/or any past medical diagnosis of eating disorder
• Major psychiatric disorder
• History of suicide attempt
• History of seizures
• Uncontrolled hypertension
• History of structural heart defect
• History of clinically significant arrhythmia
• History of cholelithiasis
• History of nephrolithiasis
• Untreated thyroid disorder

Laborértékek

• Alanine transaminase (ALT) or aspartate transaminase (AST) >/= 2.5 times the upper limit of normal
• Bicarbonate 18 mmol/L
• Creatinine > 1.2 mg/dL
• Creatinine clearance <50 mL/min (Schwartz formula)

Egyéb

• Tanner stage 1-4
• Patient Health Questionnaire-9 (PHQ-9) score of >/= 15 at screening
• Unstable clinically-diagnosed depression
• Suicidal ideation of type 4 or 5 on the Columbia-Suicide Severity Rating Scale (C-SSRS) at any time during the study
• Current pregnancy or breastfeeding
• Plans to become pregnant
• If sexually active, refusal to use 2 forms of birth control
• Tobacco use
• Diagnosed monogenic obesity
• Hyperthyroidism

• Age 18 to M 25 at screening
• BMI >/= 25 to < 30 kg/m\^2
• Family history of obesity defined as one biological parent with severe obesity (BMI >/= 35) and/or two biological parents with obesity (BMI >/=30). Parental obesity status will be confirmed by obtaining a release of information to review and electronic health record.