A Study to Investigate Efficacy and Safety of Brivekimig in Participants With Crohn's Disease

Korábbi kezelés

• Participants with following ongoing known complications of CD:
  • Any manifestation that might require bowel surgery while enrolled in the study
  • Participant with ostomy or ileoanal pouch
  • Participant diagnosed with conditions that could interfere with drug absorption including but not limited to short bowel syndrome
  • Participant with surgical bowel resection within the past three months prior to screening, or a history of >3 bowel resections

Más betegség

• Participants with active Ulcerative Colitis (UC), indeterminate colitis, adenomatous colonic polyps not excised, colonic mucosal dysplasia (low- or high-grade dysplasia) or short bowel syndrome
• History of any other condition which, in the opinion of the Investigator, would put the participant at risk by participation in the study
  • The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Egyéb

• Participants with CD isolated to the stomach, duodenum, jejunum, or perianal region, without colonic or ileal involvement

• Diagnosis of Crohn's Disease (CD) for at least 3 months prior to screening
• Confirmed diagnosis of moderate-to-severe CD
• History of prior exposure to standard treatment and having inadequate response to, loss of response to or intolerance to standard therapy with any of the following compounds: (5-Amino Salicylates (5-ASAs), 6-Mercaptopurine (6-MP), Azathioprine (AZA), Methotrexate (MTX), oral or corticosteroids or advanced therapies (ATs) (biologics or small molecules), but having inadequate response to, loss or response to or intolerance to at least one of these therapies
• On stable doses of standard treatments prior to screening (Oral 5-ASA compounds, Oral corticosteroids, AZA, 6-MP, or MTX, or Antibiotics, etc.)
• Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies