NCT06964438Toboroz
Postoperative Electrical Muscle Stimulation Two
A Three-Arm Randomised Controlled Trial to Establish Effectiveness of NMES With or Without Protein Supplementation to Preserve Muscle Mass and Strength and Improve Functional Outcomes After Abdominal Surgery for GI Cancer
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. jún. 15.
Rövid összefoglaló (regiszter, angolul)
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity. Losing muscle can lead to a reduction in one's ability to perform physical activities, and reduce independence and overall health. Muscle mass loss occurs very quickly (i.e., within a few days) after surgery. The investigators previous work has shown that neuromuscular electrical stimulation (NMES) of the thigh muscles on one side of the body can help maintain muscle mass and strength on the stimulated side after surgery. Since then, additional work has been carried out to find the most effective form of stimulation to build muscle. The current study aims to use this refined stimulation protocol in a clinical trial on the wards after major abdominal surgery. The intervention will involve delivering stimulation to both thighs in the few days after surgery, so that the investigators can assess whether this stimulation can preserve muscle mass and strength, and also, patients' ability to perform physical activities after surgery. In addition, the study will aim to find out whether any benefit provided by electrical stimulation can be increased further by taking a protein supplement at the same time.
- Állapot (regiszter)
- Toboroz
- Vizsgálattípus
- Beavatkozással járó
- Résztvevők száma
- 45 (tervezett)
- Első benyújtás
- 2025. ápr. 22.
- Kezdés
- 2025. jún. 5.
- Elsődleges befejezés
- 2027. febr. 1.
- Fő szponzor
- University of Nottingham
- Betegségek
- Vastagbélrák
- NCT-szám
- NCT06964438
Mit vállalsz
- Vizsgálat típusa: Beavatkozással járó
- Tervezett résztvevők: 45
- 2025. jún. 5. és az elsődleges befejezés (2027. febr. 1.) között
- 1 helyszín, 1 országban
- Vizitek és vizsgálatok: kérdezd a vizsgálat csapatát, a regiszter nem sorolja fel őket
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Korábbi kezelés
- Disability preventing completion of ERAS after surgery (requiring Zimmer frame/wheeled frame/wheelchair to mobilise or bed-bound)
- Intubation or intensive care admission during study period (between day 0-5 post-op); (surgical high dependency unit patients will be included)
- Return to theatre for surgical complication within first 5-days post operation
Más betegség
- Upper GI (gastrointestinal) cancer requiring thoracotomy/thoracoscopy
- Pre-existing neuromuscular disease (including Parkinsons disease)
- Pacemaker, implantable cardiac defibrillator or other implanted nerve stimulator device
- Dementia or other cognitive problem or language barrier causing an inability to follow instructions and operate NMES machine
- Peripheral vascular disease
- Epilepsy
- Pre-existing diagnosis of chronic kidney disease or estimated glomerular filtration rate <60 on screening visit
- Pre-existing diagnosis of liver disease
- History of rhabdomyolysis
- Deep vein thrombosis within past 6-months
- Allergy to whey protein
- Known infection with blood borne virus
Egyéb
- Metal prostheses or other metal-work in either upper legs (hip/knee/femur)
- Inability to give informed consent
- Pregnancy
- Patient refusal of whey protein products on grounds of dietary requirements or intolerance
- Participating in another clinical trial concurrently or within the last 6 months
Kiket keres a vizsgálat
- Adult patients (age 18 or over at the time of diagnosis made at MDT (multi-disciplinary team meeting)
- MDT outcome of colorectal or gastric cancer or non-invasive neoplasia (tissue-proven, or radiologically diagnosed and clinically suspected) with the intention to treat with curative abdominal surgery
- Agreed management plan for open or minimally invasive (laparoscopic or robot assisted) segmental abdominal (colonic or gastric) resection at the Royal Derby Hospital
- Sufficient mobility and fitness to complete normal ERAS (enhanced recovery after surgery) protocols following surgery
- Basic conversational spoken English language
- Ability to give informed consent
Életkor a regiszterben: 18 év – - · Nem: nők és férfiak · Egészséges önkénteseket nem fogad
Helyszínek (1)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Royal Derby Hospital | Derby | Egyesült Királyság | Toboroz |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.