Vibegron for ENergy Thinking and Resilience in Aging

Korábbi kezelés

• Prior weight loss procedure (e.g., gastric bypass, sleeve gastrectomy, gastric banding)
• Regular use of the following: weight loss medications (e.g., Orlistat, Belviq, Contrave, Saxenda, Phentermine, Qsymia); medications or dietary supplements known to alter energy metabolism; adrenergic agonists or beta blockers
• Symptoms of urinary retention, incontinence, urgency, and frequency or current use of an antimuscarinic medication to treat overactive bladder
• Drug/substance abuse or excessive alcohol use within the past 6 months

Más betegség

• Evidence of cognitive impairment
• Significant medical illness or organ failure, such as uncontrolled hypertension, advanced kidney disease, liver disease, thyroid disease, or active neoplastic disease
• Diagnosis of a neurodegenerative illness (e.g., mild cognitive impairment, dementia, Parkinson's disease, Multiple Sclerosis)
• History of a clinically significant stroke
• Cardiac arrhythmia or an abnormal Electrocardiogram

Laborértékek

• Uncontrolled diabetes (hemoglobin A1c >7%)

Egyéb

• Body weight ≥450 pounds
• Major depression
• Weight gain or loss of ≥5% over the past 6 months
• Benign prostate hyperplasia
• Contraindication to Vibegron or any of its components
• Current participation in another intervention or research study that prohibits co-enrollment

• Obese (BMI ≥30 kg/m2 or BMI ≥27 kg/m2 with a waist circumference >102 cm for men and >88 cm for women)