Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure

Korábbi kezelés

• Other Diuretics: Requirement for a diuretic other than furosemide, bumetanide, or torsemide (except for spironolactone, eplerenone, finerenone, or SGLT2 inhibitors) at randomization or during the study.
• Recent Cardiovascular Events: Myocardial infarction, stroke, transient ischemic attack, acute kidney injury, or acute HF requiring hospitalization within 30 days prior to randomization.
• Recent Participation in Clinical Trials: Participation in another clinical trial within the last three months prior to randomization.
• Requirements for treatment with a non-steroidal anti-inflammatory drug (except for Aspirin up to 200 mg as PRN daily).

Más betegség

• Severe Lung Disease: Severe or symptomatic lung disease or respiratory symptoms distinct from HF.
• Urinary Issues: History of urinary incontinence, or inability to empty the bladder.
• Uncontrolled Comorbidities: Uncontrolled diabetes mellitus or hypertension.
• Cardiac Conditions: History of flash pulmonary edema or amyloid cardiomyopathy.

Laborértékek

• Renal Dysfunction: Estimated GFR < 30 ml/min/1.72m².
• Serum potassium concentration <3.5 or >5.5 mmol/L.

Egyéb

• Breastfeeding: Female participants who are breastfeeding.

• Age: 18 years or older.
• Informed Consent: Willing and able to sign the informed consent form.
• Stable Chronic HF: A clinical diagnosis of chronic heart failure considered stable by the patient's cardiologist/physician or another experienced clinician for at least one month prior to randomization.
• Current Diuretic Therapy: Receiving an oral dose of 20 mg to 80 mg daily of furosemide, or 10 mg to 40 mg daily dose of torsemide, or 1 mg to 4 mg daily dose of bumetanide, for about 30 days prior to randomization.
• Stable HF Medications: No anticipated changes in HF medications during the study period.
• Female Participants: Premenopausal women of childbearing potential must have a negative pregnancy test prior to study initiation and agree to use effective contraceptive methods throughout the study period.