A Trial of HRS-5965 Capsule in Primary IgA Nephropathy

Korábbi kezelés

• Allergic to any RAS blockers, investigational products, or components as evaluated by the investigator;
• Have any organ transplant;
• Patients with active infection of tuberculosis within 1 year prior to screening, such as liver abscess and pyelonephritis; Or subjects with active infection who requiring intravenous antibiotic therapy within 2 weeks prior to randomization;
• Patients with a history of severe trauma or major surgery within 12 weeks prior to screening, or who plan to undergo surgery during the study period;
• Patients with a history of blood donation or a history of severe blood loss (≥400 mL blood loss) within 12 weeks prior to screening, or who have received blood transfusions within 12 weeks prior to screening;
• Participants who have participated in a clinical trial of any drug or medical device within 12 weeks prior to randomization and are expected to have residual effects of the investigational treatment (as determined by the investigator), or who were within the follow-up period of a clinical study, or within 5 half-lives of the investigational drug, or within 30 days (whichever is older) before screening;
• Participants who received systemic glucocorticoid or immune suppressants within 12 weeks prior to randomization and are expected to have during research；
• Participants who received biologics or cytokine inhibitor within 6 months prior to randomization and are expected to have during research；

Más betegség

• Patients with a history of immunodeficiency disease; Or in combination with other systemic diseases likely to cause proteinuria; Or with Nephrotic Syndrome;
• Patients with a history of malignant neoplasms;
• The presence of a disease or medical condition determined by the investigator might affect drug absorption, distribution, metabolism, and excretion;
• As determined by the investigator, the subject has any of the following: progression or recovery of a disease;
• A history of drug abuse;
• Any physical or mental illness or condition that, as determined by the investigator, is likely to increase the risk of the study, affect the subject's adherence to the protocol, or prevent the subject from completing the study.

Laborértékek

• Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), or total bilirubin exceeding 3 times the upper limit of normal (ULN) at screening;

Egyéb

• Patients with secondary IgA nephropathy as determined by the investigator;
• IgA nephropathy with rapid decline of renal function; Kidney pathology indicated that more than 50% of the glomerulus had large crescent body formation, which may affect the study results; Tubule atrophy - interstitial fibrosis of more than 50%;
• Women who are pregnant or breastfeeding;

• Able and willing to provide a written informed consent；
• Weight ≥35 kg, Body mass index (BMI) < 37.5kg /m2;
• Primary IgA nephropathy was confirmed by renal biopsy within 8 years;
• 24-UPE≥ 1.0g /24h, or 24-UPCR≥ 0.8g/g at screen, and 24-UPCR≥ 0.8g/g prior to randomization;
• eGFR≥30 ml/min/1.73m2 at screening and prior to randomization; (CKD-EPI formula)
• A fertile female subject or a male subject whose partner is a fertile female, who has not had a fertility, sperm/egg donation plan from the signing of the informed consent to 1 month after the last dose, and voluntarily takes effective contraceptive measures (including the partner);
• Understand the research procedures and methods, voluntarily participate in this trial, and sign the informed consent form in person.
• Receiving optimal supportive therapy including RAS blockers and stabilizing the dose for at least 12 weeks after reaching the maximum recommended dose or the maximum tolerated dose prior to randomization;