An Open-label Study of CND261 in Seropositive Rheumatoid Arthritis

Korábbi kezelés

• Receipt of or inability to discontinue any excluded therapies
• Receipt of live vaccine within 4 weeks
• Presence of any concomitant autoimmune disease
• APS or thrombotic event not adequately controlled by anticoagulation therapy
• Presence of 1 or more significant concurrent medical conditions
• Major surgery requiring use of general anesthesia within 12 weeks or planned or expected major surgery during the study

Más betegség

• Active infection
• Active or known history of catastrophic anti-phospholipid syndrome
• History of progressive multifocal leukoencephalopathy
• Central nervous system disease
• Have a diagnosis or history of malignant disease within 5 years
• Serious mental illness, alcohol or drug abuse, dementia, or any other condition that would impair ability to receive planned treatment or to understand informed consent
• History of or planned organ transplant and/or autologous or allogeneic hematopoietic stem cell transplantation

Laborértékek

• Inadequate clinical laboratory parameters at Screening

Egyéb

• Women who are pregnant or breastfeeding
• Patients who do not agree to the use of highly effective contraception as defined by the protocol

• 18 to 75 years old
• Diagnosis of adult-onset RA
• Class I-III RA
• Moderately to severely active RA
• Inadequate treatment response as defined in the protocol
• Stable use of any concomitant therapies