Parkinson's Research In Metagenomic Early Stage Biomarkers

Korábbi kezelés

• Chronic corticosteroid therapy;
• Use of proton pump inhibitors within the past 30 days;
• Prolonged intake of anxiolytic drugs, antidepressants, antipsychotics, cognitive stimulants, and analogs in the past 3 months;
• Use of experimental products in the 3 months prior to the screening visit

Más betegség

• Pre-existing psychiatric disorders;
• Any other neurological or neurodegenerative disorders;
• Dementia diagnosis;
• Type1 Diabetes Mellitus;
• Type 2 diabetes mellitus with HbA₁c ≥ 8% or on insulin therapy;
• Acute diseases;
• Celiac disease;
• History of major gastrointestinal surgery or acute GI conditions (e.g., gastroenteritis) within the past 3-6 months;
• Acute, antibiotic-resistant infections;
• History of deep brain stimulation (DBS) surgery;

Egyéb

• Atypical or secondary Parkinsonism;
• Presence of pacemakers or other subcutaneous electronic devices;
• Moderate to severe cognitive decline;
• Beck Depression Inventory-II (BDI-II)\] score ≥28;
• Thyroid dysfunctions;
• Active Neoplasia;
• IBD or IBS;
• Antibiotic intake within the past 30 days;
• Prebiotic/probiotic supplement use in the past 30 days;
• Underweight (BMI \<18.5);
• Pregnancy or lactation;
• Regular use of enemas or suppositories to alleviate constipation;
• Patients who, for medical reasons, are required to follow special dietary regimens that could interfere with the adoption or effectiveness of the Mediterranean model;
• Vegan/Vegetarian diet or any other dietary behaviour that excludes one or more of the typical food groups of the Mediterranean model.

• Diagnosis of Parkinson's disease according to United Kingdom (UK) Parkinson's Disease Society Brain Bank criteria;
• aged 35-80 years;
• Hoehn \& Yahr stage \> 1 and \< 3 in the clinical "ON" state;
• MoCA score ≥17.54;
• MMSE ≥24;
• Stable dopaminergic midication regimen for ≥ 4 weeks;
• Ability to interact with the research team and provide informed consent in Italian;
• Suitable to physical exercise;
• Able to walk unassisted (no walking aids);
• Willingness and ability to comply with all study procedures;
• Willingness to maintain usual diet during a ≥ 4-week pre-baseline period;
• Willingness to switch to a Mediterranean-style diet during the intervention;
• Ability to provide stool samples at each collection timepoint;
• Willing to avoid strenuous exercise and alcohol for 24 hours prior to each visits.