[18F]AlF-NOTA-octreotide PET/MRI in Carotid Artery Disease

Korábbi kezelés

• Participant has a previous or ongoing recurrent or chronic disease at high risk to interfere with the performance or evaluation of the trial, according to the judgment of the investigator
• Participants treated with carotid endarterectomy or carotid artery stenting within the past year
• Concurrent treatment with corticosteroids and/or somatostatin analogues

Más betegség

• Participants with a cardio-embolic stroke, small vessel stroke or other defined stroke etiology according to the TOAST classification (23)

Laborértékek

• Subject has an impaired renal function estimated glomerular filtration rate (eGFR) < 40 ml/min/1.73m² (the last known value may not date from more than 3 months prior to the study PET/MR; if not available a blood analysis may be performed as part of the trial)

Egyéb

• Female who is pregnant or breast-feeding
• Subject has a contra-indication for or cannot tolerate MR scanning
• Subject is unwilling or unable to perform all of the study procedures, or is considered unsuitable in any way by the principal investigator

• Participant is aged over 18 years.
• Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedure
• CT angiography imaging at baseline should be available as part of routine care
• Participant is diagnosed with a recent ischemic stroke or high-risk TIA (ABCD2 ≥ 4) in the carotid artery territory and ≥ 30% carotid artery stenosis. The stroke/TIA has occurred no more than 21 days prior to tracer administration.