Comparison of 18F Labeled Analog of MIBG (18F-MFBG) PET/CT and 123I-MIBG SPECT in Pediatric Patients With Neuroblastoma.

Korábbi kezelés

• Pregnant or breastfeeding patient. If indicated, at the investigator's discretion, patients of childbearing potential should have urinary pregnancy test the day of the PET/CT procedure, prior to the MFBG administration.

Más betegség

• Patient with a parent or legal representative with altered mental status or psychiatric disorder that, in the opinion of the investigator, would preclude a valid informed consent

Egyéb

• Patient inability to comply with protocol requirements without general anesthesia.
• Any treatment likely to interact with MIBG initiated/modified between scintigraphy with MIBG and PET/CT with MFBG.

• Patients with histologically proven neuroblastoma.
• Relapsed or refractory neuroblastoma.
• 123I-MIBG avid neuroblastoma (positive 123I-MIBG scintigraphy = showing at least one neuroblastoma lesion (either primary or metastatic) with a significant avidity for 123I-MIBG), performed within 2 weeks to 2 days prior to 18F-MFBG PET/CT.
• No specific treatment for neuroblastoma between 123I-MIBG scintigraphy and 18F-MFBG PET/CT (PET/CT shall not delay therapeutic management.)
• Age ≥ 365 days to \< 18 years old. For children under 13 months, day of birth should be collected.
• Weight ≥ 9 kg.
• Performance Status: Lansky or Karnofsky ≥ 60%.
• Signed written informed consent by the 2 holders of the parental authority or legal representative(s).
• Patients covered by a health insurance system.