A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

Korábbi kezelés

• Previous small bowel resection with combined resected length of > 100 cm or previous colonic resection of > 2 segments
• Received IV corticosteroids within 14 days prior to Screening or during the Screening Phase
• Previous total proctocolectomy or subtotal colectomy

Más betegség

• Current evidence or within recent history (within last 6 months) of fulminant colitis, toxic megacolon, or bowel perforation

Egyéb

• Diagnosis of indeterminate colitis
• Suspected or diagnosed intra-abdominal or perianal abscess at Screening
• CD isolated to the stomach, duodenum, jejunum, or perianal region, without colonic and/or ileal involvement
• Current stoma or impending need for colostomy or ileostomy

• Diagnosis of Crohn's Disease (CD), as confirmed by endoscopy and histopathology
• Moderately to severely active CD as defined by Clinical Disease Activity Index (CDAI) and Simple Endoscopic Score (SES-CD)
• Meets drug stabilization requirements
• Diagnosis of Ulcerative Colitis (UC), as confirmed by endoscopy and histopathology
• Moderately to severely active UC as defined by a 3-component MMCS
• Meets drug stabilization requirements