A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC

Korábbi kezelés

• Receiving investigational treatment in addition to other clinical studies (in the treatment phase of a clinical study)
• There are factors affecting surgery or anesthesia, such as severe organ dysfunction
• Long-term use of immunosuppressive agents after organ transplantation

Más betegség

• Accompanied by severe uncontrolled infection or medical illness
• Major organ dysfunction, such as decompensated heart, lung, kidney, and liver failure, cannot tolerate NACI or surgical treatment
• Patients with a history of other malignant tumors before enrollment

Egyéb

• Presence of distant metastasis
• Women who are pregnant or lactating
• Patients who are unable to cooperate with regular follow-up due to psychological, social, family and geographical reasons

• Oral squamous cell carcinoma or oropharyngeal squamous cell carcinoma diagnosed as locally advanced (T3-4) according to the AJCC criteria
• Their age ranged from 18 to 80 years
• There was no history of other malignant tumors or treatment
• Adequate blood function: white blood cell count (WBC) ≥3.5×10\^9/L, platelet count (PLT) ≥75×10\^9/L; Hemoglobin concentration (HGB) ≥90g/L
• Adequate liver function: total bilirubin (TBIL) ≤ the upper limit of normal, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 times the upper limit of normal
• "Adequate renal function: urinary white blood cells < 10, red blood cells < 10, cast count < 5 per high-power field, and creatinine (CRE) ≤ the upper limit of normal.
• The heart, brain, lung and other vital organs function and general condition can tolerate NACI and surgical treatment
• PS score ≤2