Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban

Más betegség

• History of atrial fibrillation or atrial flutter, or 12-lead Electrocardiogram before randomization and after admission showing atrial flutter or atrial fibrillation;
• Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage, or a history of bleeding within one month;
• The following drugs are taken within one week: dual antiplatelet drugs, direct oral anticoagulants (DOACs), warfarin and other drugs that increase the risk of bleeding;
• Severe uncontrolled hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
• Severe renal insufficiency and advanced disease with an expected life expectancy of less than 6 months;
• Allergy to drugs or contrast agents;
• Other conditions that the researcher deems unsuitable for participation in this study.

Laborértékek

• Deficiency of anticoagulant factors or international normalized ratio (INR) > 1.7, platelet count < 90×10⁹/L;;

Egyéb

• Intracranial aneurysms or malformations, tortuous arteries that hinder thrombectomy, and space-occupying effect brain tumors;
• Pregnancy or lactation;
• Participating in other clinical trials;

• Age ≥ 18 years;
• Anterior circulation large vessel occlusion (the internal carotid artery or the first or second segment of the middle cerebral artery) confirmed by computed tomography angiography (CTA) or magnetic resonance angiography (MRA);
• Eligible for endovascular treatment within 12 hours of symptom onset;
• Based on the patient's medical history, clinical presentation, and imaging findings, large artery atherosclerosis is highly suspected as the underlying etiology;
• Baseline National Institute of Health Stroke Scale (NIHSS) ≥ 6;
• Baseline ASPECTS ≥ 6 on CT;
• A pre-stroke modified Rankin Scale (mRS) score of ≤2;
• Signed informed consent by patient or their legally authorized representative.