Selenium Supplementation for Improving Depression in Children and Adolescents: Efficacy and Mechanistic Study

Korábbi kezelés

• Patients currently taking medications contraindicated with the investigational drug or that may interfere with its efficacy;
• Those who have received modified electroconvulsive therapy (MECT) within the past 12 months;

Más betegség

• Patients with severe psychiatric disorders such as bipolar disorder, schizophrenia, bulimia nervosa, anorexia nervosa, or primary obsessive-compulsive disorder;
• Those with severe physical illnesses or other life-threatening conditions; patients in a current depressive episode with a clear suicidal plan or history of suicide attempt;
• Individuals with a history of substance or drug abuse;
• Those requiring immediate hospitalization for psychiatric disorders;
• Individuals allergic to selenium yeast protein, including those with allergic rhinitis, gastrointestinal sensitivity, allergic constitution, or autoimmune diseases such as Graves' disease or Hashimoto's thyroiditis;

Egyéb

• Patients with contraindications to magnetic resonance imaging (MRI);
• Left-handed individuals.

• Aged 12-18 years;
• Diagnosed with major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), using the K-SADS-PL diagnostic tool;
• A score of ≥40 on the Children's Depression Rating Scale-Revised (CDRS-R);
• Adequate visual and auditory abilities to complete the study;
• Willingness to participate in the study with informed consent signed by both the participant and a legal guardian.