Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

Korábbi kezelés

• Use of other medications known to affect the motility of the stomach.
• Current treatment with insulin or insulin secretagogues that might increase risk of hypoglycaemia during periods of fasting.
• Recurrent severe hypoglycaemia (more than 1 severe hypoglycaemic event within 180 days) or hypoglycaemic unawareness as judged by the investigator or hospitalisation for diabetic ketoacidosis within 180 days before screening

Más betegség

• Presence of clinically significant gastrointestinal disorders or symptoms of gastrointestinal disorders potentially affecting absorption of drugs or nutrients, or as judged by the investigator.
• History of major surgical procedures involving the oesophagus or stomach potentially affecting absorption of trial products (e.g. subtotal and total gastrectomy, sleeve gastrectomy, gastric bypass surgery) or current presence of gastrointestinal implant.
• Diagnosed with or suspected to suffer from clinically significant gastroparesis, hiatal hernia or severe gastro-oesophageal reflux diseases with daily symptoms and/or in supine position.

Laborértékek

• Glycosylated hemoglobin (HbA1c) > 6.5 percent (%) 48 millimole per mole (mmol/mol) at screening.
  • For participants with T2D:
• HbA1c ≥ 10.5 % (91 mmol/mol) at screening.

Egyéb

• Inability to lie in the right lateral decubitus position for gastric ultrasonography.
• Unusual meal habits and special diet requirements or unwillingness to eat the meals provided in the study.
  • For participants without T2D:

• Male or female.
• Age 18 years or above at the time of signing the informed consent.
• BMI between 25.0 and 45 kilogram per meter square (kg/m\^2) (both inclusive) at screening. Overweight should be due to excess adipose tissue, as judged by the investigator.
  • For participants with T2D:
• Diagnosed with type 2 diabetes (T2D) more than (>) 180 days before screening.
• Treatment with:
  • no antidiabetic drugs or
  • stable metformin dose or both [stable dose is defined as the maximum daily tolerated dose for more than or equal to (≥) 90 days before screening]