Not yet taking people in Kína3. fázis

Ongericimab Injection Reducing Recurrence of Ischemic Stroke

Key facts

Where: Anshun, Baise City, Baoding, Baotou, Bayan Nur, Beijing, Benxi, Binzhou, Changchun, Changde, Changsha, Changzhi, Chenzhou, Chifeng, Chongqing, Dalian, Dandong, Daqing, Dezhou, Dingxi, Dongying, Fushun, Fuyang, Haikou, Handan, Harbin, Hebi, Heihe, Hejian, Hengshui, Heze, Hohhot, Huai'an, Huizhou, Huludao, Huzhou, Jiamusi, Jiaozuo, Jiaxing, Jingdezhen, Jining, Jiujiang, Jiuquan, Jixi, Jiyuan, Kaili, Lanzhou, Liaocheng, Linfen, Lishui, Liuzhou, Loudi, Luoyang, Meihekou, Meishan, Nanyang, Ningde, Nujiang, Pingdingshan, Pu'er, Puyang, Qingdao, Qinhuangdao, Qiqihar, Sanmenxia, Shanghai, Shangqiu, Shangrao, Shaoguan, Shaoxing, Shenmu, Shenyang, Shijiazhuang, Shizuishan, Shuangyashan, Shuozhou, Siping, Suining, Suqian, Tai’an, Taiyuan, Tangshan, Tianshui, Tieling, Tonghua, Tongliao, Tongren, Ürümqi, Weifang, Weihai, Wenzhou, Wuhan, Wuhu, Xi'an, Xianning, Xingtai, Xining, Xinxiang, Xinyang, Xuchang, Yakeshi, Yan’an, Yangquan, Yantai, Yibin, Yongzhou, Zhalantun, Zhangjiakou, Zhanjiang, Zhengzhou, Zhoukou és Zhumadian, KínaSee the 197 sites
Phase: 3. fázis

Where in Kína

Puding County People's HospitalAnshun, KínaNo longer taking part
Baise City People's HospitalBaise City, KínaNo longer taking part
Affiliated Hospital of Hebei UniversityBaoding, KínaNo longer taking part
Hebei Tang County People's HospitalBaoding, KínaNo longer taking part
The No.2 Hospital Of BaodingBaoding, KínaNo longer taking part
Baotou City Central HospitalBaotou, KínaNo longer taking part
Sinopharm North HospitalBaotou, KínaNo longer taking part
Bayannur HospitalBayan Nur, KínaNo longer taking part
WuYuan County People's HospitalBayan Nur, KínaNo longer taking part
Beijing Tiantan Hospital,Capital Medical UniversityBeijing, KínaNo longer taking part
The First Hospital of Fangshan District, BeijingBeijing, KínaNo longer taking part
Benxi Central HospitalBenxi, KínaNo longer taking part
General Hospital of Benxi IronBenxi, KínaNo longer taking part
Binzhou Medical University HospitalBinzhou, KínaNo longer taking part
Yangxin County People's HospitalBinzhou, KínaNo longer taking part
China-Japan Union Hospital of JiLin UniversityChangchun, KínaNo longer taking part
Taoyuan People'S HospitalChangde, KínaNo longer taking part
Liuyang Jili HospitalChangsha, KínaNo longer taking part
Changzhi People's HospitalChangzhi, KínaNo longer taking part
Chenzhou 3rd People's HospitalChenzhou, KínaNo longer taking part
Chenzhou No.1 People's HospitalChenzhou, KínaNo longer taking part
Affiliated Hospital of Chifeng UniversityChifeng, KínaNo longer taking part
Chifeng City Center Hospital Ningcheng CountyChifeng, KínaNo longer taking part
Chifeng Hospital of Traditional Chinese and Mongolian MedicineChifeng, KínaNo longer taking part
Ningcheng County Hospital of Traditional Chinese and Mongolian MedicineChifeng, KínaNo longer taking part
Chongqing Sanbo Changan HospitalChongqing, KínaNo longer taking part
The Fifth People's Hospital of ChongqingChongqing, KínaNo longer taking part
The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqing, KínaNo longer taking part
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)Dalian, KínaNo longer taking part
Dalian Jinzhou District First People's HospitalDalian, KínaNo longer taking part
Dalian Lvshunkou District Traditional Chinese Medicine HospitalDalian, KínaNo longer taking part
Dalian University Affiliated Xinhua HospitalDalian, KínaNo longer taking part
The First Affiliated Hospital of Dalian Medical UniversityDalian, KínaNo longer taking part
Wafangdian Third Hospital Co., Ltd.Dalian, KínaNo longer taking part
Dandong Central HospitalDandong, KínaNo longer taking part
Dandong First HospitalDandong, KínaNo longer taking part
DA QING LongNan HospitalDaqing, KínaNo longer taking part
Daqing No.4 hospitalDaqing, KínaNo longer taking part
Daqing Oilfield General HospitalDaqing, KínaNo longer taking part
Ningjin People's HospitalDezhou, KínaNo longer taking part
People's Hospital of Qihe CountyDezhou, KínaNo longer taking part
Minxian County Hospital of Traditional Chinese MedicineDingxi, KínaNo longer taking part
The Second People's Hospital of DongyingDongying, KínaNo longer taking part
Liaoning Health Industry Group Fukuang General HospitalFushun, KínaNo longer taking part
Fuyang People's HospitalFuyang, KínaNo longer taking part
The Second Affiliated Hospital of Hainan Medical UniversityHaikou, KínaNo longer taking part
Cixian People's HospitalHandan, KínaNo longer taking part
Handan Central HospitalHandan, KínaNo longer taking part
Qiuxian County People's HospitalHandan, KínaNo longer taking part
Weixian People's HospitalHandan, KínaNo longer taking part
Beian No.1 People's HospitalHarbin, KínaNo longer taking part
The 2nd Affiliated Hospital of Harbin Medical UniversityHarbin, KínaNo longer taking part
The First Affiliated Hospital of Harbin Medical UniversityHarbin, KínaNo longer taking part
Hebi Coal Industry (Group) Co., Ltd. General HospitalHebi, KínaNo longer taking part
No.1 People'S Hospital of HeiheHeihe, KínaNo longer taking part
Hejian People's HospitalHejian, KínaNo longer taking part
Hengshui People's HospitalHengshui, KínaNo longer taking part
The NO.4 People's Hospital of HengshuiHengshui, KínaNo longer taking part
Yuncheng County People's HospitalHeze, KínaNo longer taking part
Tuoketuo County HospitalHohhot, KínaNo longer taking part
Lianshui County People's HospitalHuai'an, KínaNo longer taking part
Huidong People's HospitalHuizhou, KínaNo longer taking part
Huizhou First HospitalHuizhou, KínaNo longer taking part
Huludao Central HospitalHuludao, KínaNo longer taking part
Huzhou Central HospitalHuzhou, KínaNo longer taking part
The First Affiliated Hospital of Jiamusi UniversityJiamusi, KínaNo longer taking part
The Hongda Hospital of Jiamusi UniversityJiamusi, KínaNo longer taking part
Jiaozuo Coal Mining Group Co., Ltd. Central HospitalJiaozuo, KínaNo longer taking part
Mengzhou Fuxing hospitalJiaozuo, KínaNo longer taking part
Mengzhou Hospital of Traditional Chinese MedicineJiaozuo, KínaNo longer taking part
Qinyang City Hospital of Traditional Chinese MedicineJiaozuo, KínaNo longer taking part
Qinyang People's HospitalJiaozuo, KínaNo longer taking part
The First Affiliated Hospital of Henan Polytechnic University (Jiaozuo Second People's Hospital)Jiaozuo, KínaNo longer taking part
Xiuwu County People's HospitalJiaozuo, KínaNo longer taking part
Haiyan People's HospitalJiaxing, KínaNo longer taking part
The First People's Hospital of JingdezhenJingdezhen, KínaNo longer taking part
Qufu People's HospitalJining, KínaNo longer taking part
Jiujiang No.1 People's HospitalJiujiang, KínaNo longer taking part
Shanghai General Hospital Jiuquan HospitalJiuquan, KínaNo longer taking part
Mudanjiang Hospital of Beidahuang GroupJixi, KínaNo longer taking part
Jiyuan Hospital of Traditional Chinese MedicineJiyuan, KínaNo longer taking part
The People's Hospital of the Qiandongnan Miao and Dong Autonomous PrefectureKaili, KínaNo longer taking part
Gansu Provincial Maternity and Child-care Hospital(Gansu Provincial Central Hospital)Lanzhou, KínaNo longer taking part
The First People's Hospital of Yuzhong CountyLanzhou, KínaNo longer taking part
Liaocheng Brain HospitalLiaocheng, KínaNo longer taking part
Liaocheng City Central HospitalLiaocheng, KínaNo longer taking part
Liaocheng People's HospitalLiaocheng, KínaNo longer taking part
The People's Hospital of GaotangLiaocheng, KínaNo longer taking part
The people's Hospital of LinqingLiaocheng, KínaNo longer taking part
The Third People Hospital in LiaochengLiaocheng, KínaNo longer taking part
Linfen Central HospitalLinfen, KínaNo longer taking part
Lishui Central HospitalLishui, KínaNo longer taking part
Liuzhou Worker's HospitalLiuzhou, KínaNo longer taking part
Lianyuan People's HospitalLoudi, KínaNo longer taking part
Luoyang Central HospitalLuoyang, KínaNo longer taking part
Luoyang First People's HospitalLuoyang, KínaNo longer taking part
The Second Affiliated Hospital of Henan University of Science and TechnologyLuoyang, KínaNo longer taking part
Meihekou Central HospitalMeihekou, KínaNo longer taking part
Meishan Cardio Cerebrovascular Disease HospitalMeishan, KínaNo longer taking part
People'S Hospital of TangheNanyang, KínaNo longer taking part
Ningde People's HospitalNingde, KínaNo longer taking part
The People's Hospital of Nujiang Lisu Autonomous PrefectureNujiang, KínaNo longer taking part
Pingdingshan The second people's hospitalPingdingshan, KínaNo longer taking part
The First People's Hospital of PingdingshanPingdingshan, KínaNo longer taking part
Ninger People's HospitalPu'er, KínaNo longer taking part
Chinese Medicine Hospital of PuyangPuyang, KínaNo longer taking part
Nanle People's HospitalPuyang, KínaNo longer taking part
Puyang County People's HospitalPuyang, KínaNo longer taking part
Puyang Oilfield General HospitalPuyang, KínaNo longer taking part
Puyang People's HospitalPuyang, KínaNo longer taking part
Qingdao Cardiovascular Hospital Co., Ltd.Qingdao, KínaNo longer taking part
The Second Hospital of QinhuangdaoQinhuangdao, KínaNo longer taking part
Tianjin Cancer Hospital Qinhuangdao BranchQinhuangdao, KínaNo longer taking part
The Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar, KínaNo longer taking part
Sanmenxia Central HospitalSanmenxia, KínaNo longer taking part
The First People Hospital of LingbaoSanmenxia, KínaNo longer taking part
Yellow River Sanmenxia HospitalSanmenxia, KínaNo longer taking part
Liqun Hospital, Putuo District, ShanghaiShanghai, KínaNo longer taking part
Shanghai Fourth People's Hospital Affiliated to Tongji UniversityShanghai, KínaNo longer taking part
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of MedicineShanghai, KínaNo longer taking part
People's hospital of NingLingShangqiu, KínaNo longer taking part
Shang Qiu Hospital of TcmShangqiu, KínaNo longer taking part
Sui county traditional Chinese medicine hospitalShangqiu, KínaNo longer taking part
Yugan Xinjiang hospitalShangrao, KínaNo longer taking part
Shaoguan Qujiang District People's HospitalShaoguan, KínaNo longer taking part
Shaoxing People's HospitalShaoxing, KínaNo longer taking part
Shenmu HospitalShenmu, KínaNo longer taking part
Central Hospital Affiliated to Shenyang Medical CollegeShenyang, KínaNo longer taking part
Northern Theater Command Air Force HospitalShenyang, KínaNo longer taking part
Northern Theater Command General HospitalShenyang, KínaNo longer taking part
The First People's Hospital of ShenyangShenyang, KínaNo longer taking part
The People's Hospital of Liaoning ProvinceShenyang, KínaNo longer taking part
The Second Hospital of Hebei Medical UniversityShijiazhuang, KínaNo longer taking part
Xingtang County People's HospitalShijiazhuang, KínaNo longer taking part
Xinji Traditional Chinese Medicine HospitalShijiazhuang, KínaNo longer taking part
The Fifth People's Hospital of NingxiaShizuishan, KínaNo longer taking part
The third hospital of shi zui shanShizuishan, KínaNo longer taking part
Hongxinglong Hospital of Beidahuang GroupShuangyashan, KínaNo longer taking part
Grand Hospital of ShuozhouShuozhou, KínaNo longer taking part
Siping City Central People's HospitalSiping, KínaNo longer taking part
Suining Center HospitalSuining, KínaNo longer taking part
Siyang Kangda HospitalSuqian, KínaNo longer taking part
The Second Affiliated Hospital of Shandong First Medical UniversityTai’an, KínaNo longer taking part
First Hospital of Shanxi Medical UniversityTaiyuan, KínaNo longer taking part
Second hospital of Shanxi Medical UniversityTaiyuan, KínaNo longer taking part
Shanxi Cardiovascular HospitalTaiyuan, KínaNo longer taking part
Guye District Hospital of Traditional Chinese Medicine, TangshanTangshan, KínaNo longer taking part
Yutian County Hospital of Traditional Chinese MedicineTangshan, KínaNo longer taking part
First People's Hospital of TianshuiTianshui, KínaNo longer taking part
The First Hospital of Xifeng CountyTieling, KínaNo longer taking part
Tonghua Dongchang District People's HospitalTonghua, KínaNo longer taking part
Tongliao People's HospitalTongliao, KínaNo longer taking part
Tongren People's HospitalTongren, KínaNo longer taking part
Xinjiang Production&Construaction Corps HospitalÜrümqi, KínaNo longer taking part
People's Hospital of Changle CountyWeifang, KínaNo longer taking part
People's Hospital of GaomiWeifang, KínaNo longer taking part
Weifang People's HospitalWeifang, KínaNo longer taking part
Weihai Central HospitalWeihai, KínaNo longer taking part
Weihai Wendeng District People's HospitalWeihai, KínaNo longer taking part
Affiliated Yueqing Hospital of Wenzhou Medical UniversityWenzhou, KínaNo longer taking part
Department of Yongjia People's HospitalWenzhou, KínaNo longer taking part
Zhongnan Hospital of Wuhan UniversityWuhan, KínaNo longer taking part
The First Affiliated Hospital of Wannan Medical CollegeWuhu, KínaNo longer taking part
The Second Affiliated Hospital of Xi'an Medical UniversityXi'an, KínaNo longer taking part
Xi 'an Fengcheng HospitalXi'an, KínaNo longer taking part
Xianning Central HospitalXianning, KínaNo longer taking part
Qinghe people's hospitalXingtai, KínaNo longer taking part
Weixian People's HospitalXingtai, KínaNo longer taking part
Xingtai central hospitalXingtai, KínaNo longer taking part
Xingtai People's HospitalXingtai, KínaNo longer taking part
Qinghai Provincial Traffic HospitalXining, KínaNo longer taking part
The First Affiliated Hospital of Henan Medical UniversityXinxiang, KínaNo longer taking part
People's Hospital of XixianXinyang, KínaNo longer taking part
Changge People's HospitalXuchang, KínaNo longer taking part
Inner Mongolia Forestry General HospitalYakeshi, KínaNo longer taking part
Zichang People's HospitalYan’an, KínaNo longer taking part
The First People's Hospital of YangquanYangquan, KínaNo longer taking part
Qixia Traditional Chinese Medicine HospitalYantai, KínaNo longer taking part
Yantai Hospital of Traditional Chinese MedicineYantai, KínaNo longer taking part
Yantai Penglai traditional Chinese medicine hospitalYantai, KínaNo longer taking part
Yantai Taocun Central HospitalYantai, KínaNo longer taking part
Yantai Yuhuangding HospitalYantai, KínaNo longer taking part
YEDA hospitalYantai, KínaNo longer taking part
Jiang'an County Hospital of Traditional Chinese MedicineYibin, KínaNo longer taking part
The Affiliated Hospital of Yongzhou Vocational and Technical CollegeYongzhou, KínaNo longer taking part
Zhalantun Hospital of Traditional Chinese and Mongolian MedicineZhalantun, KínaNo longer taking part
Zhalantun People's HospitalZhalantun, KínaNo longer taking part
Xuangang HospitalZhangjiakou, KínaNo longer taking part
Wuchuan People's HospitalZhanjiang, KínaNo longer taking part
Xingyang People's HospitalZhengzhou, KínaNo longer taking part
Xinmi Hospital of T.C.MZhengzhou, KínaNo longer taking part
Taikang Xian People's HospitalZhoukou, KínaNo longer taking part
Zhoukou Yongshan HospitalZhoukou, KínaNo longer taking part
The First People's Hospital of ZhumadianZhumadian, KínaNo longer taking part
The People's Hospital Of Biyang CountyZhumadian, KínaNo longer taking part
The People's Hospital of Queshan CountyZhumadian, KínaNo longer taking part
Zhumadian Central HospitalZhumadian, KínaNo longer taking part

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Trial details

Who runs it: Beijing Tiantan Hospital
Trial code: NCT07242599
Record updated: 2026. április 16.
Original description: The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by achieving lower lipid-lowering target values (LDL-C < 1.4 mmol/L).Read full original descriptionShow less
A Multicenter, Randomized, Open-label, Parallel-controlled, Event-driven, Blinded-endpoint Trial Evaluating the Efficacy and Safety of Ongericimab Injection in High-risk Stroke Patients With Intracranial or Extracranial Atherosclerotic Stenosis.
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by achieving lower lipid-lowering target values (LDL-C < 1.4 mmol/L).
Inclusion: Obtaining informed consent；; Age ≥18 years；; Patients with ischemic stroke within 3 months( NIHSS<15 before randomization); Presence of ≥50% stenosis in major intracranial or extracranial arteries, and related to the symptoms of the current episode or the location of infarction；; LDL-C ≥ 70 mg/dL (1.8 mmol/L) at screening.
Exclusion: Hypothyroidism diagnosed within 1 month before randomization; NYHA Class III/IV heart failure within 1 year prior to randomization; PCSK9 inhibitor use within 3 months before randomization; Participation in other drug/device trials within 30 days; History of cerebral hemorrhage at any time (microhemorrhages present only on SWI are not an exclusion criterion); Hemorrhage or other pathological neurological conditions on baseline brain CT/MRI (e.g., vascular malformations, tumors, abscesses, or common non-ischemic brain diseases like multiple sclerosis); Stroke caused by angioplasty/vascular surgery; Cardioembolic stroke caused by atrial fibrillation, artificial heart valves, endocarditis, mitral stenosis, sinus node dysfunction, etc; Uncontrolled hypertension (SBP >180 mmHg or DBP >110 mmHg); Malignancy within 10 years (excluding adequately treated basal cell carcinoma, cervical CIS, DCIS, or stage 1 prostate cancer); Known hypersensitivity to monoclonal antibody therapies; Inability to understand or comply with the study due to mental illness, cognitive, or emotional disorders, or other reasons deemed unsuitable for participation in the study by the investigator; Most recent fasting triglycerides >400 mg/dL (4.5 mmol/L) prior to randomization; Severe renal impairment (eGFR <30 mL/min/1.73m²); Active liver disease or dysfunction (AST/ALT >3×ULN within 30 days pre-randomization); Life-limiting non-cardiovascular diseases (life expectancy <1 years); Presence of isolated sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness or vertigo, but no evidence of recent infarction on baseline head CT or MRI; Unable to complete the assessment of intracranial and extracranial arterial stenosis before randomization; mRS score≥2 before onset (based on assessment of medical history); Women of childbearing potential without contraception, pregnancy, or lactation.
ClinicalTrials.gov NCT07242599