PET Guided Dose Reduction for InvOlved Site Radiotherapy In Early sTage Unfavourable Hodgkin Lymphoma

Korábbi kezelés

• Pre-treatment with chemotherapy or radiation therapy

Más betegség

• Active HBV and HCV infection
• HIV seropositivity
• Malignant disease within the last 5 years (excluding basal skin tumors and carcinoma in situ of the cervix)
• Significant history of neurologic, psychiatric, endocrinological, metabolic, immunologic, or hepatic disease that would preclude participation in the study or compromise ability to give informed consent.

Laborértékek

• Hodgkin Lymphoma as "composite lymphoma" or nodular lymphocyte prevalence histological subtype

Egyéb

• Patients who meet any of the following criteria are not eligible to enroll:
• Stage II B- III- IV
• Women who are pregnant or breast feeding
• Absence of FDG-avid lymphoma lesions on baseline PET scan

• Age ≥18 years;
• Histologically confirmed classical HL stage I, II unfavorable according to GHSG criteria;
• Patient with any nodal mass ≥ than 10 cm can be included
• No previous treatment for Hodgkin lymphoma;
• ECOG performance status 0 to 2;
• Presence of FDG-avid lymphoma lesions on baseline PET scan;
• Subject understands and voluntarily signs the informed consent form approved by the Independent Ethics Committee (IEC), prior to the initiation of any screening or study-specific procedures;
• Adequate organ and marrow function as defined below:
  • absolute neutrophil count > 1.0 x109/L
  • platelet count > 75 x109/L
  • Total bilirubin < 2 mg/dl without a pattern consistent with Gilbert's syndrome
  • Aspartate Transaminase and Alanine Transaminase (AST/ALT) < 3.0 X institutional Upper Limits of Normality (ULN)
  • Creatinine within normal institutional limits or creatinine clearance > 50 mL/min
• Women of childbearing potential must agree to use a highly effective method of contraception (oral contraceptives, contraceptive injections, contraceptive patch, intrauterine device) from the signature of informed consent until six months after the last dose of treatment;
• Men must agree to use a highly effective method of contraception (barrier contraception or abstinence, when this is in line with the usual lifestyle of the subject) from the signature of informed consent until six months after the last dose of treatment;
• Women of childbearing potential must have a negative serum pregnancy test at screening.