Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Anterior Circulation Large Vessel Occlusion Stroke -2

Korábbi kezelés

• Concurrent malignant tumors or severe systemic diseases with expected survival of less than 90 days;
• Participation in another interventional clinical study within 30 days before randomization or currently participating in another interventional clinical study;

Más betegség

• Intracerebral hemorrhage, epidural hematoma, subdural hematoma, intraventricular hemorrhage, or subarachnoid hemorrhage;
• Pre-stroke modified Rankin scale (mRS) score >1;
• Known allergy to tocilizumab or excipients;
• Known allergy to iodinated contrast agents;
• History of congenital or acquired bleeding disorders, coagulation factor deficiency diseases, or thrombocytopenic diseases;
• Severe mental disorders or inability to comply with informed consent and follow-up requirements due to dementia;
• Presence of autoimmune diseases or use of immunosuppressive drugs;
• Systemic infectious diseases;
• Considered by the investigator to have other conditions that might affect compliance or preclude participation in this study.

Laborértékek

• Neutrophils <2×109 /L;
• Platelets <100×109 /L;
• Blood glucose <2.8mmol/L (50 mg/dL) or >22.2mmol/L (400 mg/dL);
• Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels >2 times the upper limit of normal;
• Known recent or current serum creatinine >2 times the upper limit of normal or estimated glomerular filtration rate (eGFR) <60 mL/min;

Egyéb

• Anticipated difficulty in completing endovascular treatment due to vascular tortuosity;
• Systolic blood pressure ≥180mmHg or diastolic blood pressure ≥110mmHg despite blood pressure control;
• Pregnant, lactating, or planning pregnancy within 90 days;

• Age 18 years or greater, male or female;
• Acute ischemic stroke caused by occlusion of intracranial segment of the internal carotid artery, middle cerebral artery M1 or proximal/dominant M2 segment;
• Decided to undergo emergency endovascular treatment;
• Time from stroke onset to arterial puncture within 24 hours;
• National Institutes of Health Stroke Scale (NIHSS) score ≥ 6;
• Signed informed consent from the patients or the legally authorized representatives.