Effect of Roxadustat on Heart Failure Patients With Anaemia and Moderate-to-Severe Chronic Kidney Disease

Korábbi kezelés

• participation in a drug clinical trial within one year.

Más betegség

• comorbid myelodysplastic syndromes, multiple myeloma, hereditary hematologic diseases (e.g., thalassemia, sickle cell anaemia, pure red cell aplasia), hemosiderosis, hemochromatosis, or other disorders confirmed to cause anaemia due to erythrocyte destruction and/or abnormal hematopoietic function;
• bilateral nephrectomy, kidney transplantation within ≤6 months, or congenital kidney diseases (e.g., polycystic kidney disease);
• hypertrophic obstructive cardiomyopathy or congenital heart disease with right-to-left shunt;
• comorbid malignancy with an investigator-assessed life expectancy of less than 12 months;
• known allergy to the study drug (active ingredient or excipients);

Laborértékek

• haemoglobin level ≤45 g/L on two or more blood tests, a history of major bleeding within one year, or a history of anaemia corrected by blood transfusion;

Egyéb

• pregnancy or lactation;

• aged 18-85 years, regardless of gender;
• fulfilled the diagnostic criteria for heart failure and chronic kidney disease;
• haemoglobin level <130 g/L for men or <120 g/L for women at baseline;
• had regularly received Roxadustat for over one year;
• possessed complete clinical data, including information from pre-specified time points.