An Exploratory Study on the Use of Ivosidenib for the Precise Treatment of Advanced Biliary Tract Malignancies With IDH1 Mutations in the Later Line of Therapy.

Korábbi kezelés

• Prior Treatment: Previous treatment with Ivosidenib.
• Recent Therapy: Local anti-tumor therapy or major surgery within 4 weeks prior to initiation.
• Concurrent Participation: Participation in another interventional clinical trial.

Más betegség

• Cancer Type: Ampulla of Vater cancer.
• Allergy: Known hypersensitivity to any component of the study drugs.
• Medical Conditions:
• Uncontrolled hypertension.
• Significant cardiovascular disease.
• Active autoimmune disease.
• Uncontrolled active infection (e.g., HBV, HCV, HIV).
• Significant bleeding tendency or history.
• History of organ transplantation.

Egyéb

• Pregnancy： Pregnant or breastfeeding women.
• Active or untreated CNS metastases.
• Severe non-healing wounds.

• Voluntary Participation: Signed informed consent.
• Genetic Mutation: Presence of an IDH1 mutation confirmed by genetic testing.
• Disease Status：
• Newly diagnosed, untreated advanced/metastatic disease; OR
• Recurrence >6 months after curative-intent surgery (with or without adjuvant therapy).
• Measurable Disease: At least one measurable lesion per RECIST 1.1.
• Performance Status: ECOG performance status of 0 or 1.
• Life Expectancy： ≥3 months.
• Organ Function: Adequate hematological, hepatic, and renal function.
• Contraception: Use of highly effective contraception for women of childbearing potential and men.