NCT07294924Leállítva
Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements
PREDICT-ACC: Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements
Forrás: ClinicalTrials.gov · Utoljára frissítve: 2026. szept. 10.
Megadott ok: Terminated due to low enrollment.
Rövid összefoglaló (regiszter, angolul)
This observational, longitudinal, multi-cohort study aims to evaluate functional brain activity in adults undergoing treatment for Major Depressive Disorder (MDD) at participating clinical sites. A separate cohort of healthy adults will be enrolled as a control group. All data collected in this study are for research purposes only and will not influence clinical decision-making or treatment plans. This study will use TD-fNIRS to measure hemodynamic brain responses at rest and/or during tasks in patients receiving accelerated transcranial magnetic stimulation (TMS). Imaging will occur at multiple timepoints (pre-treatment, post-treatment, and follow-ups). Healthy control participants will complete similar measurements at one visit, with the option for a follow-up visit. The primary objectives are to assess feasibility, characterize brain activity patterns, and explore potential biomarkers associated with treatment response.
- Állapot (regiszter)
- Leállítva
- Vizsgálattípus
- Megfigyeléses
- Résztvevők száma
- 11 (tényleges)
- Első benyújtás
- 2025. dec. 8.
- Kezdés
- 2026. jan. 1.
- Elsődleges befejezés
- 2026. márc. 12.
- Fő szponzor
- Kernel
- Betegségek
- Depresszió
- NCT-szám
- NCT07294924
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Korábbi kezelés
- Has had electroconvulsive therapy (ECT) in the past 3 months
Más betegség
- Major medical illnesses including neurological and psychiatric conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, schizophrenia, or stroke.
- Any other clinically significant medical condition that in the opinion of the clinician or study team, could affect patient safety, wellbeing, or the participant's ability to comply with study procedures.
Egyéb
- All cohorts
- Pregnant or may become pregnant during the treatment course
- Unable or unwilling to wear the fNIRS headset
- Not an appropriate candidate for the study based on the discretion of the study investigator(s).
- Healthy controls cohort only
- Clinical diagnosis of depression in the past year
- Undergoing any treatments for depression in the past year
Kiket keres a vizsgálat
- Accelerated TMS cohort
- Adults aged 18-75 at the time of enrollment
- Primary diagnosis of MDD as defined by the DSM-5
- Determined by the clinic to be eligible for accelerated rTMS treatment and agrees to receive accelerated rTMS treatment
- Agrees to start accelerated rTMS treatment in conjunction with study participation to capture baseline measurements
- Has not received rTMS treatment in the past 1 month
- Has not received SPRAVATO treatment in the past 1 month
- Can speak and understand English
- Ability to provide informed consent
- Healthy controls cohort
- Adults aged 18-75 at time of enrollment
- Can speak and understand English
- Ability to provide informed consent
Életkor a regiszterben: 18 év – 75 év · Nem: nők és férfiak · Egészséges önkénteseket is fogad
Helyszínek (2)
Helyszínek a regiszter sorrendjében. Ha a profilodba mented a városodat, távolság szerint rendeződnek.
| Helyszín | Város | Ország | Helyszín állapota |
|---|---|---|---|
| Kernel | Los Angeles | Egyesült Államok | Ismeretlen állapot |
| Acacia Clinics | Sunnyvale | Egyesült Államok | Ismeretlen állapot |
Ez az oldal tájékoztatás, nem orvosi tanács. Bármely vizsgálatról az orvosoddal beszélj.